Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Antibacterial effects of Mume Fructus Water Extract against Salmonella typhimurium in Murine Salmonellosis

  • Jung, Won-Chul (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Cha, Chun-Nam (Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University) ;
  • Lee, Hu-Jang (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2009.08.27
  • Accepted : 2009.10.10
  • Published : 2009.10.31
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Abstract

The present study was undertaken to estimate the antibacterial effect of Mume Fructus water extract (MFWE) against murine salmonellosis. At MFWE concentrations ranging from 25 to 100 ${\mu}g/ml$, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, bacteria without MFWE had a tendency to proliferate up to 8 h after incubation. Oral administration of MFWE at the dose of 40 mg/ml showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of MFWE-treated mice was 80% at 12 days, while that of MFWE-untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that MFWE has potential as an effective of salmonellosis.

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