Preventive Nutrition and Food Science

  • 제14권2호
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  • Pages.102-108
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  • 2009
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  • 2287-1098(pISSN)
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  • 2287-8602(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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The Comparative Immunomodulatory Effects of β-Glucans from Yeast, Bacteria, and Mushroom on the Function of Macrophages

  • Jang, Seon-A (Department of Herbal Medicine Resource, Kangwon National University, Institute of Bioscience and Biotechnology) ;
  • Park, Sul-Kyoung (Department of Herbal Medicine Resource, Kangwon National University, Institute of Bioscience and Biotechnology) ;
  • Lim, Jung-Dae (Department of Herbal Medicine Resource, Kangwon National University, Institute of Bioscience and Biotechnology) ;
  • Kang, Se-Chan (Department of Natural Medicine Resources, Semyung University) ;
  • Yang, Kwang-Hee (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd) ;
  • Pyo, Suh-Kneung (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Sohn, Eun-Hwa (Department of Herbal Medicine Resource, Kangwon National University, Institute of Bioscience and Biotechnology)
  • 발행 : 2009.06.30
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초록

The comparative immunomodulatory effects of ${\beta}$-glucans isolated from mushroom fungi (Coriolus versicol), yeast (Saccharomyces cerevisiae) and bacteria (Agrobacterium) on the major functions of macrophages were evaluated. As parameters of macrophage functions, we examined tumoricidal activity, phagocytosis, nitric oxide (NO) production, and the induction of inducible NO synthetase (iNOS) in RAW264.7 cells, following treatments with ${\beta}$-glucans from the three different sources. The results indicated that all ${\beta}$-glucan treatments significantly induced tumoricidal activity in the RAW264.7 cells, with a remarkable effect shown by the beta-glucan from Agrobacterium at a concentration of $10{\mu}g/mL$. There was also a significant increase in iNOS-NO system activity in macrophages treated with ${\beta}$-glucans extracted from yeast; however, iNOS-NO system activity was not markedly changed by the treatment of ${\beta}$-glucans from C. versicolor mushroom fungi or Agrobacterium. Furthermore, the ${\beta}$-glucans from C. versicolor had a significant phagocytotic effect at concentrations of 1, 10, and $100{\mu}g/mL$. Taken together, the present data suggest that these ${\beta}$-glucans, isolated from three different sources, have different effects on macrophage function, and therefore, may have different clinical uses in different for various types of diseases.

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피인용 문헌

  1. Phagocytic Effects of β-Glucans from the Mushroom Coriolus versicolor are Related to Dectin-1, NOS, TNF-α Signaling in Macrophages vol.19, pp.4, 2011, https://doi.org/10.4062/biomolther.2011.19.4.438
  2. Optimization for Production of Phellinus linteus Mycelia with Anti-Complement Activity vol.53, pp.3, 2010, https://doi.org/10.3839/jabc.2010.032
  3. Effects of Beta-glucan from Coriolus versicolor on Scavenger Receptor B1 Expression and their Involvement of Dectin-1 and Casein Kinase 2 vol.25, pp.6, 2012, https://doi.org/10.7732/kjpr.2012.25.6.664
  4. vol.47, pp.1, 2019, https://doi.org/10.1080/21691401.2018.1559180