Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Mechanism of Vascular Relaxation of Ethanol Extract of Persicaria Perfoliata H. Gross

하백초 에탄올 추출물의 혈관이완 기전에 대한 연구

  • Kim, Hye-Yoom (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Byung-Sun (College of Oriental Medicine, Wonkwang University) ;
  • Choi, Eun-Hee (College of Oriental Medicine, Wonkwang University) ;
  • Cui, Hao-Zhen (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김혜윰 (원광대학교 한의학전문대학원) ;
  • 최병선 (원광대학교 한의과대학) ;
  • 조은희 (원광대학교 한의과대학) ;
  • 최호진 (원광대학교 한의학전문대학원) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원)
  • Published : 2009.04.25
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Abstract

The ethanol extract of Persicaria perfoliata (EPP) induced relaxation of the phenylephrine-precontracted aorta in a dose-dependent manner, which was abolished by removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4}-oxadiazole-[4,3-${\alpha}$)-quinixalin-1-one (ODQ) inhibited the relaxation induced by EPP. However, EPP-induced relaxation was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolol. Incubation of endothelium-intact thoracic aortic ring with EPP increased the production of cGMP, which was also blocked by pretreatment with L-NAME or ODQ. These results suggest that EPP dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.

Keywords

References

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