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Study on the Mechanism of Vascular Relaxation of Ethanol Extract of Persicaria Perfoliata H. Gross  

Kim, Hye-Yoom (Professional Graduate School of Oriental Medicine, Wonkwang University)
Choi, Byung-Sun (College of Oriental Medicine, Wonkwang University)
Choi, Eun-Hee (College of Oriental Medicine, Wonkwang University)
Cui, Hao-Zhen (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.2, 2009 , pp. 389-396 More about this Journal
Abstract
The ethanol extract of Persicaria perfoliata (EPP) induced relaxation of the phenylephrine-precontracted aorta in a dose-dependent manner, which was abolished by removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4}-oxadiazole-[4,3-${\alpha}$)-quinixalin-1-one (ODQ) inhibited the relaxation induced by EPP. However, EPP-induced relaxation was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolol. Incubation of endothelium-intact thoracic aortic ring with EPP increased the production of cGMP, which was also blocked by pretreatment with L-NAME or ODQ. These results suggest that EPP dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.
Keywords
ethanol extract of Persicaria perfoliata (EPP); aortic tissues; endothelium; nitric oxide/cGMP; vascular relaxation;
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