Physical Therapy Korea (한국전문물리치료학회지)

Korean Research Society of Physical Therapy (한국전문물리치료학회)
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Effects of Low and Moderate Intensity Treadmill Exercise on Functional Recovery and Histological Changes After Spinal Cord Injury in the Rats

척수손상 백서모델에서 저강도 및 중강도 트레드밀 운동이 운동기능회복 및 조직학적 변화에 미치는 영향

  • Kim, Gi-Do (Dept. of Physical Therapy, Dongshin University) ;
  • Kim, Gye-Yeop (Dept. of Physical Therapy, Dongshin University) ;
  • Kim, Eun-Jung (Dept. of Physical Therapy, Dongshin University)
  • 김기도 (동신대학교 물리치료학과) ;
  • 김계엽 (동신대학교 물리치료학과) ;
  • 김은정 (동신대학교 물리치료학과)
  • Published : 2009.05.21
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Abstract

This study was designed to investigate the effects of treadmill exercise of low-intensity and moderate- intensity on the functional recovery and histological change in spinal cord injury (SCI) rats. SCI was induced by the spinal cord impactor dropped after laminectomy. Experimental groups were divided into the Group I (normal control), Group II (non-treatment after SCI induction), Group III (low-intensity treadmill exercise after SCI induction), Group IV (moderate-intensity treadmill exercise after SCI induction). After operation, rats were tested at modified Tarlov scale at 2 days with divided into 4 groups, and motor behavior test (BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in spinal cord, histopathological studies were performed at 21 days by H & E, and BDNF(brain-derived neutrophic factor) & Trk-b immunohistochemistry studies were performed at 1, 3, 7, 14, 21 days. According to the results, treadmill exercise can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, moderate-intensity treadmill exercise after SCI induction was most improvement in functional recovery and histological change.

Keywords

References

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