Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Fabrication and Characterization of PVA/CMC Hydrogels by Freezing-Thawing Technique and Gamma-Ray Irradiation

동결/융해와 방사선 가교법에 의한 PVA/CMC 수화젤의 제조 및 특성 평가

  • Jo, Sun-Young (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lim, Youn-Mook (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Youn, Min-Ho (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Jong-Seok (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Nho, Young-Chang (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Shin, Heung-Soo (Department of Bioengineering, Division of Applied Chemical and Bio Engineering, Hanyang University)
  • 조선영 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 임윤묵 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 윤민호 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 권희정 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 박종석 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 노영창 (한국원자력연구원 정읍 방사선과학연구소 방사선공업환경연구부) ;
  • 신흥수 (한양대학교 대학원 생명공학과)
  • Published : 2009.11.25
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Abstract

Poly (vinyl alcohol) (PVA) and carboxymethyl cellulose (CMC) have received increasing attention in biomedical and biochemical applications because of their properties such as being water-soluble and biocompatible. In this study, a PVA/CMC hydrogel applicable to artificial cartilage was prepared by a freezing-thawing technique and a gamma-ray irradiation. The solid concentration of PVA was 7 wt% and the concentration of CMC was 4 wt%. The freezing/thawing process was repeated twice and the dose of gamma-ray irradiated was 30 kGy. Results of gelation before and after gamma-ray irradiation were similar, but the swelling degree decreased and compressive strength increased. The cytotoxicity was investigated with CCK-8 assay.

Poly(vinyl alcohol) (PVA)와 carboxymethyl cellulose sodium salt(CMC)는 우수한 생체적합성 및 수용성으로 인하여 생체의학 분야에서 주목하는 재료 중 하나이다. 본 연구에서는 PVA와 CMC를 동결/융해 과정과 감마선 조사에 의하여 인공연골로서 사용 가능한 수화젤을 제조하였다. 수화젤 제조시 PVA/CMC의 농도는 PVA는 7 wt%, CMC는 4 wt%로 고정시켰으며, 동결/융해 과정은 2회 반복하였으며, 감마선은 30 kGy조사하였다. 방사선 조사 전과 후의 겔화율은 눈에 띄는 차이는 보이지 않았으나 팽윤도는 조사 후에 감소하였으며, 겔강도는 증가하였다.CCK-8 assay에 의하여 세포독성이 없는 것으로 확인되었다. 제조된 PVA/CMC 수화젤은 체내에 삽입되는 인공연골 재료로서 사용가능성을 제시하였다.

Keywords

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