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Fabrication and Characterization of PVA/CMC Hydrogels by Freezing-Thawing Technique and Gamma-Ray Irradiation  

Jo, Sun-Young (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Lim, Youn-Mook (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Youn, Min-Ho (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Gwon, Hui-Jeong (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Park, Jong-Seok (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Nho, Young-Chang (Radiation Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Shin, Heung-Soo (Department of Bioengineering, Division of Applied Chemical and Bio Engineering, Hanyang University)
Publication Information
Polymer(Korea) / v.33, no.6, 2009 , pp. 551-554 More about this Journal
Abstract
Poly (vinyl alcohol) (PVA) and carboxymethyl cellulose (CMC) have received increasing attention in biomedical and biochemical applications because of their properties such as being water-soluble and biocompatible. In this study, a PVA/CMC hydrogel applicable to artificial cartilage was prepared by a freezing-thawing technique and a gamma-ray irradiation. The solid concentration of PVA was 7 wt% and the concentration of CMC was 4 wt%. The freezing/thawing process was repeated twice and the dose of gamma-ray irradiated was 30 kGy. Results of gelation before and after gamma-ray irradiation were similar, but the swelling degree decreased and compressive strength increased. The cytotoxicity was investigated with CCK-8 assay.
Keywords
PVA; CMC; gamma-ray irradiation; hydrogel;
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