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Anti-Platelet Aggregation Effect of Extract from Gamisopunghwalheol-tang in Vitro  

Lee, Hae-Yong (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Min, Kyoung-Yoon (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Kim, Seul-Ji (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Park, Youn-Ju (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Yang, Ga-Eun (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Lee, Mi-Jung (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Lew, Jae-Whan (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University)
Lee, Beom-Joon (Department of Internal Medicine, Kangnam Korean Hospital, Kyunghee University)
Cho, In-Young (Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.5, 2009 , pp. 980-985 More about this Journal
Abstract
The study was designed to test anti-platelet effect and find out anti-platelet mechanism of extract from Gamisopunghwalheol-tang in vitro. The extract was investigated for the inhibition against the aggregation of human platelet suspensions induced from collagen by aggregometer. And also the extract was investigated for the inhibition against the aggregation of human platelet suspensions who is taking aspirin or clopidogrel induced from collagen by aggregometer. In collagen-induced platelet aggregation test, the extract significantly inhibited collagen-induced platelet aggregation in a concentration-dependent manner(p<0.05). The extract significantly inhibited collagen-induced platelet aggregation of human platelet who is taking aspirin or clopidogrel ing 0 mg/ml concentration(p<0.05). And the extract inhibited more ingpatients who is taking aspirin. These results show that the extract from Gamisopunghwalheol-tang has anti-platelet aggregation effect.
Keywords
gamisopunghwalheol-tang; antiplatelet activity; aggregometer;
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Times Cited By KSCI : 1  (Citation Analysis)
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