Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effect of Lecithin on Dermal Safety of Nanoemulsion Prepared from Hydrogenated Lecithin and Silicone Oil

  • Bae, Duck-Hwan (Department of Chemistry, Chungbuk National University) ;
  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University) ;
  • Shin, Gwi-Su (Jeonbuk Regional Innovation Agency) ;
  • Jin, Fan-Long (School of Chemical and Materials Engineering, Jilin Institute of Chemical Technology) ;
  • Park, Soo-Jin (Department of Chemistry, Inha University)
  • Published : 2009.04.20
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Abstract

In this study, a hydrogenated lecithin-containing nanoemulsion was prepared from hydrogenated lecithin and silicone oil. Tween-60 and liquid paraffin, widely known emulsifiers, were used as standard substances, and high shear was produced by utilizing a high shear homogenizer and microfluidizer. The properties of the nanoemulsion prepared with hydrogenated lecithin were evaluated by measuring interfacial tension, dynamic interfacial tension, droplet size, zeta-potential, friction force, skin surface hygrometery, and dermal safety. The interfacial tension of lecinol S10/silicone oil was lower than that of lecinol S10/liquid paraffin. The nanoemulsion prepared from hydrogenated lecithin shows lower zeta-potential, skin surface hygrometery, and friction force compared with a general emulsion. The silicone nanoemulsion prepared from hydrogenated lecithin showed a zero value in the patch test and thus exhibits high dermal safety.

Keywords

References

  1. Evans, D. F.; Wennerstrom, H. The Colloidal Domain; Wiley-VCH, New York, 1999; p 51.
  2. Bernard, F. S.; List, R. L. Lecithins; American Oil Chemists' Society: New York, 1985.
  3. Joshia, A.; Paratkarb, S. G.; Thorata, B. N. Eur. J. Lipid Sci. Technol. 2006, 108, 363. https://doi.org/10.1002/ejlt.200600016
  4. Nii, T.; Ishii, F. Colloids Surf. B Biointerf. 2005, 41, 305. https://doi.org/10.1016/j.colsurfb.2004.12.017
  5. Bunjes, H.; Koch, M. H. J. J. Control. Release 2005, 107, 229. https://doi.org/10.1016/j.jconrel.2005.06.004
  6. Nii, T.; Takamura, A.; Mohri, K.; Ishii, F. Colloids Surf. B Biointerf. 2002, 27, 323. https://doi.org/10.1016/S0927-7765(02)00097-8
  7. Ishii, F. Yukagaku 2000, 49, 1141.
  8. Israelachvili, J. N.; Michell, D. J.; Ninham, B. W. J. Chem. Soc. Faraday Trans. 1 1976, 72, 1525. https://doi.org/10.1039/f29767201525
  9. Seddon, J. M. Biochim. Biophys. Acta 1990, 1031, 1. https://doi.org/10.1016/0304-4157(90)90002-T
  10. Bae, D. H.; Shin, J. S.; Jin, F. L.; Park, S. J. Bull. Korean Chem. Soc. Submitted for publication, 2008
  11. Scherze, I.; Muschiolik, G. Colloids Surf. B Biointerf. 2001, 21, 107. https://doi.org/10.1016/S0927-7765(01)00189-8
  12. Lee, Y. K.; Jin, F. L.; Park, S. J. Bull. Korean Chem. Soc. 2007, 28, 1493. https://doi.org/10.5012/bkcs.2007.28.9.1493
  13. Park, S. J.; Lee, Y. M.; Hong, S. K. Colloids Surf. B Biointerf. 2006, 47, 211. https://doi.org/10.1016/j.colsurfb.2005.12.001
  14. Alvarez, M. A.; Seyler, D.; Madrigal-Carballo, S.; Vila, A. O.; Molina, F. J. Colloid Interface Sci. 2007, 309, 279. https://doi.org/10.1016/j.jcis.2007.02.026
  15. H$\ddot{u}$bert, T.; Svoboda, S.; Oertel, B. Surf. Coat. Technol. 2006, 201, 487. https://doi.org/10.1016/j.surfcoat.2005.11.014
  16. Smith, J. R.; Laver, D. R.; Coster, H. G. L. Chem. Phys. Lipid 1984, 34, 227. https://doi.org/10.1016/0009-3084(84)90057-4
  17. Fang, J. Y.; Hwang, T. L.; Fang, C. L.; Chiu, H. C. Int. J. Pharm. 2003, 255, 153. https://doi.org/10.1016/S0378-5173(03)00086-3

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