Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and 17O NMR

  • Kim, Hee-Kyung (Department of Medical & Biological Engineering, Kyungpook National University) ;
  • Lee, Gang-Ho (Department of Chemistry, Kyungpook National University) ;
  • Kim, Tae-Jeong (Department of Applied Chemistry, Kyungpook National University) ;
  • Chang, Yong-Min (Department of Medical & Biological Engineering, Kyungpook National University)
  • Published : 2009.04.20
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Abstract

The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time $({\tau}_R)$, the water residence time $({\tau}_m)$, and the longitudinal electronic spin relaxation time $(T_{le})$(T_1e) for two new gadolinium complexes 1 and 2 of the type [$Gd(L)(H_2O)$] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [$Gd(DTPA)(H_2O)]2‐ (Magnevist${\circledR}$), [Gd(DTPA-BMA)(H2O)] (Omniscan${\circledR}$), and $[Gd(DOTA)(H_2O)]^-$ (Dotarem${\circledR}$). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in ${\tau}_R$.

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