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http://dx.doi.org/10.5012/bkcs.2009.30.4.849

Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and 17O NMR  

Kim, Hee-Kyung (Department of Medical & Biological Engineering, Kyungpook National University)
Lee, Gang-Ho (Department of Chemistry, Kyungpook National University)
Kim, Tae-Jeong (Department of Applied Chemistry, Kyungpook National University)
Chang, Yong-Min (Department of Medical & Biological Engineering, Kyungpook National University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.4, 2009 , pp. 849-852 More about this Journal
Abstract
The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time $({\tau}_R)$, the water residence time $({\tau}_m)$, and the longitudinal electronic spin relaxation time $(T_{le})$(T_1e) for two new gadolinium complexes 1 and 2 of the type [$Gd(L)(H_2O)$] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [$Gd(DTPA)(H_2O)]2‐ (Magnevist${\circledR}$), [Gd(DTPA-BMA)(H2O)] (Omniscan${\circledR}$), and $[Gd(DOTA)(H_2O)]^-$ (Dotarem${\circledR}$). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in ${\tau}_R$.
Keywords
MRI CA; Gadolinium chelate; Tranexamate; Correlation times;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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1 Gonzalez, G.; Powell, D. H.; Tissieres, V.; Merbach, A. E. J. Phys. Chem. 1994, 98, 53.   DOI   ScienceOn
2 Vigouroux, C.; Bardet, M.; Belorizky, E.; Fries, P. H.; Guillermo, A. Chem. Phys. Lett. 1998, 286, 93.   DOI   ScienceOn
3 Caravan, P.; Ellison, J. J.; McMurry, T. J.; Lauffer, R. B. Chem. Rev. 1999, 99, 2293.   DOI   ScienceOn
4 Rast, S.; Borel, A.; Helm, L.; Belorizky, E.; Fries, P. H.; Merbach, A. E. J. Am. Chem. Soc. 2001, 123, 2637.   DOI   ScienceOn
5 Rast, S.; Fries, P. H.; Berlorizky, E. J. Chem. Phys. 1999, 96, 1543.
6 Dutta, S.; Park, J. A.; Jung, J. C.; Chang, Y. M.; Kim, T. J. Dalton Trans. 2008, 2199.
7 Merbach, A. E.; Toth, E. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging; John Wiley & Sons, Ltd: Chichester, UK, 2001.
8 Caravan, P. Chem. Soc. Rev. 2006, 35, 512.   DOI   ScienceOn
9 Vigouroux, C.; Belorizky, E.; Fries, P. H. Eur. Phys. J. D. 1999, 5, 243.   DOI
10 Powell, D. H.; Dhubhghaill, O. M. N.; Pubanz, D.; Helm, L.; Lebedev, Y. S.; Schlaepfer, W.; Merbach, A. E. J. Am. Chem. Soc. 1996, 118, 9333.   DOI   ScienceOn
11 Powell, D. H.; Merbach, A. E.; Gonzalez, G.; Br$\ddot{u}$cher, E.; Micskei, K.; Ottaviani, M. F.; K$\ddot{o}$hler, K.; von Zelewsky, A.; Grinberg, O. Y.; Lebedev, Y. S. Helv. Chim. Acta. 1993, 76, 2129.   DOI   ScienceOn
12 Powell, D. H.; Ni Dubhghaill, O. M.; Pubanz, D.; Helm, L.; Lebedev, Y. S.; Schlaepfer, W.; Merbach, A. E. J. Am. Chem. Soc. 1996, 118, 9333.   DOI   ScienceOn
13 Clarkson, R. B.; Smirnov, A. I.; Smirnova, T. I.; Kang, H.; Belford, R. L.; Earle, K.; Freed, J. H. Mol. Phys. 1998, 96, 1325.
14 Borel, A.; Toth, E.; Helm, L.; Janossy, A.; Merbach, A. E. Phys. Chem. Chem. Phys. 2000, 2, 1311.   DOI   ScienceOn
15 Borel, A.; Helm, L.; Merbach, A. E. Chem. Eur. J. 2001, 7, 600.   DOI   ScienceOn
16 Borel, A.; Yerly, F.; Helm, L.; Merbach, A. E. J. Am. Chem. Soc. 2002, 124, 2042.   DOI   ScienceOn
17 Rast, S.; Fries, P. H.; Belorizky, E. J. Chem. Phys. 2000, 113, 8724.   DOI   ScienceOn
18 Dutta, S.; Kim, S. K.; Lee, E. J.; Kim, T. J.; Kang, D. S.; Chang, Y. M.; Kang, S. O.; Han, W. S. Bull. Korean Chem. Soc. 2006, 27, 1038.   DOI   ScienceOn
19 Dutta, S.; Kim, S. K.; Patel, D. B.; Kim, T. J.; Chang, Y. M. Polyhederon 2007, 26, 3799.   DOI   ScienceOn
20 Sk, M. N.; Park, J. A.; Chang, Y. M.; Kim, T. J. Bull. Korean Chem. Soc. 2008, 29, 1211.   DOI   ScienceOn
21 Belorizky, E.; Fries, P. H. Phys. Chem. Chem. Phys. 2004, 6, 2341.   DOI   ScienceOn
22 Micskei, K.; Helm, L.; Br$\ddot(u)$cher, E.; Merbach, A. E. Inorg. Chem. 1993, 32, 3844.   DOI
23 Swift, T. J.; Connick, R. E. J. Chem. Phys. 1962, 37, 307.   DOI
24 Toth, E.; Connac, F.; Helm, L.; Adzamli, K.; Merbach, A. E. Eur. J. Inorg. Chem. 1998, 2017.