대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
권호 표지
DOI QR코드

DOI QR Code

소포성 갑상샘 유두암종의 세침흡인 세포검사의 정확도와 Galectin-3 면역염색의 유용성

The Diagnostic Accuracy of Fine Needle Aspiration Cytology and the Diagnostic Usefulness of Galectin-3 Immunostaining for the Follicular Variant of Papillary Thyroid Carcinoma

  • 정찬권 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 신정하 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 이현승 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 이아원 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 정은선 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 최영진 (가톨릭대학교 의과대학 병원 병리학교실) ;
  • 이교영 (가톨릭대학교 의과대학 병원 병리학교실)
  • Jung, Chan-Kwon (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Shin, Jung-Ha (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Hyun-Seung (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Ah-Won (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Jung, Eun-Sun (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Choi, Yeong-Jin (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Kyo-Young (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
  • 발행 : 2008.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The cytologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) has become one of the common causes of false negative diagnoses when performing fine needle aspiration cytology (FNAC) of the thyroid gland. We retrospectively reviewed all the aspirates for which a diagnosis of FVPTC had been made based on the surgically excised specimens, regardless of the cytologic diagnosis. 145 FNACs was performed in 135 patients. The cytologic diagnoses were categorized as 2 unsatisfactory specimens (1.4%), 16 benign (11.0%), 49 atypical (33.8%) and 78 malignant lesions (53.8%). The tumor cells consistently showed significant nuclear overlapping, irregular nuclei and fine chromatin in all cases; however, nuclear grooves and inclusions were scarce. Galectin-3 immunostaining was performed on the cell blocks of 65 cases and this was positive for 45 cases (69.2%). The results of our study demonstrate that the determination of minimal cytologic criteria is needed to raise the sensitivity of detecting FVPTC by FNAC, and galectin-3 immunostaining is useful to make decisions on the surgical treatment of cytologically atypical thyroid nodules.

키워드

참고문헌

  1. Kesmodel SB, Terhune KP, Canter RJ, et al. The diagnostic dilemma of follicular variant of papillary thyroid carcinoma. Surgery 2003;134:1005-12 https://doi.org/10.1016/j.surg.2003.07.015
  2. Kesmodel SB, Terhune KP, Canter RJ, et al. The diagnostic dilemma of follicular variant of papillary thyroid carcinoma. Surgery 2003;134:discussion 1012 https://doi.org/10.1016/j.surg.2003.07.016
  3. Zidan J, Karen D, Stein M, Rosenblatt E, Basher W, Kuten A. Pure versus follicular variant of papillary thyroid carcinoma: clinical features, prognostic factors, treatment, and survival. Cancer 2003;97:1181-5 https://doi.org/10.1002/cncr.11175
  4. Jogai S, Adesina AO, Temmim L, Al-Jassar A, Amir T, Amanguno HG. Follicular variant of papillary thyroid carcinoma -- a cytological study. Cytopathology 2004;15:212-6 https://doi.org/10.1111/j.1365-2303.2004.00168.x
  5. Jain M, Khan A, Patwardhan N, Reale F, Safran M. Follicular variant of papillary thyroid carcinoma: a comparative study of histopathologic features and cytology results in 141 patients. Endocr Pract 2001;7:79-84 https://doi.org/10.4158/EP.7.2.79
  6. Wu HH, Jones JN, Grzybicki DM, Elsheikh TM. Sensitive cytologic criteria for the identification of follicular variant of papillary thyroid carcinoma in fine-needle aspiration biopsy. Diagn Cytopathol 2003;29:262-6 https://doi.org/10.1002/dc.10388
  7. Gallagher J, Oertel YC, Oertel JE. Follicular variant of papillary carcinoma of the thyroid: fine-needle aspirates with histologic correlation. Diagn Cytopathol 1997;16:207-13 https://doi.org/10.1002/(SICI)1097-0339(199703)16:3<207::AID-DC3>3.0.CO;2-C
  8. Park MI, Kang DY. Usefulness of galectin-3, cytokeratin 19, p53, and Ki-67 for the differential diagnosis of thyroid tumors. Korean J Pathol 2006;40:86-92
  9. The Papanicolaou Society of Cytopathology Task Force on Standards of Practice. Guidelines of the Papanicolaou Society of Cytopathology for fine-needle aspiration procedure and reporting. Diagn Cytopathol 1997;17:239-47 https://doi.org/10.1002/(SICI)1097-0339(199710)17:4<239::AID-DC1>3.0.CO;2-7
  10. Barbaro D, Simi U, Lopane P, et al. Thyroid nodules with microfollicular findings reported on fine-needle aspiration: invariably surgical treatment? Endocr Pract 2001;7:352-7 https://doi.org/10.4158/EP.7.5.352
  11. The Papanicolaou Society of Cytopathology Task Force on Standards of Practice. Guidelines of the Papanicolaou Society of Cytopathology for the examination of fine-needle aspiration specimens from thyroid nodules. Diagn Cytopathol 1996;15:84-9 https://doi.org/10.1002/(SICI)1097-0339(199607)15:1<84::AID-DC18>3.0.CO;2-8
  12. Redman R, Yoder BJ, Massoll NA. Perceptions of diagnostic terminology and cytopathologic reporting of fine-needle aspiration biopsies of thyroid nodules: a survey of clinicians and pathologists. Thyroid 2006;16:1003-8 https://doi.org/10.1089/thy.2006.16.1003
  13. Wang HH. Reporting thyroid fine-needle aspiration: literature review and a proposal. Diagn Cytopathol 2006;34:67-76 https://doi.org/10.1002/dc.20400
  14. Kim WB, Kim TY, Kwon HS, et al. Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer. J Korean Soc Endocrinol 2007;22:157-87 https://doi.org/10.3803/jkes.2007.22.3.157
  15. NCI Thyroid Fine Needle Aspiration State of the Science Conference: The Final Draft of the Review and Conclusions. http://thyroidfnacancergov/files/folders/769/downloadaspx; Accessed on: July 18, 2008
  16. Hong SW. Diagnostic guideline of fine needle aspiration cytology of thyroid gland and cytopathologic features of papillary carcinoma. Korean J Cytopathol 2005;16:1-9 https://doi.org/10.1111/j.1365-2303.2005.00238.x
  17. El Hag IA, Kollur SM. Benign follicular thyroid lesions versus follicular variant of papillary carcinoma: differentiation by architectural pattern. Cytopathology 2004;15:200-5 https://doi.org/10.1111/j.1365-2303.2004.00150.x
  18. Torregrossa L, Faviana P, Camacci T, et al. Galectin-3 is highly expressed in nonencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type; comparison with Hector Battifora mesothelial cell 1 immunoreactivity. Human Pathol 2007;38:1482-8 https://doi.org/10.1016/j.humpath.2007.02.013