대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
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갑상샘의 소포샘종과 소포암종의 세포 소견: 세침흡인 세포 진단의 가능성에 대한 연구

Cytologic Features of Follicular Adenoma and Follicular Carcinoma of the Thyroid: A Study on the Likelihood of Cytologic Diagnosis by Fine Needle Aspiration Cytology

  • Park, Hee-Dae (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Park, Woon-Sun (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Kim, Sun-Hee (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Choi, Seock-Hyun (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Cho, Young-Hye (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Kang, Sung-Hee (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Lee, Kyung-Bun (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Kim, Min-Gyeong (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Kim, Dong-Hoon (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Chae, Seoung-Wan (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine) ;
  • Shon, Jin-Hee (Department of Pathology, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine)
  • 발행 : 2008.09.30
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초록

Fine-needle aspiration cytology (FNAC) cannot differentiate follicular adenoma from follicular carcinoma since this distinction can only be based on the presence of capsular or vascular invasion, and this can￢not be detected on a cytologic smear. The goal of this study was to define the diagnostic cytologic findings of follicular neoplasm and the possibility of diagnosing follicular neoplasm by performing FNAC. The cases of histologically diagnosed follicular adenoma and follicular carcinoma on the thyroidectomy specimens were retrieved. Among them, the cases with preoperative FNAC that was done within 3 months of the operation were finally selected. Then we reviewed the FNAC and histologic slides of 19 cases: 9 follicular adenomas and 10 follicular carcinomas. Our results suggest that for cases of follicular neoplasm, the aspirates show high or abundant cellularity, frequent follicle formation and occasional cellular atypism of the follicular cells. However, the atypism is more pronounced and more frequently noticed in the cases of follicular carcinoma, which reveals more higher anisocytosis (7/10, 70%), nuclear pleomorphism (9/10, 90%), coarse clumping of chromatin (8/10, 80%) and cellular overlapping (8/10, 80%).

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참고문헌

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