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http://dx.doi.org/10.3338/kjc.2008.19.2.160

The Diagnostic Accuracy of Fine Needle Aspiration Cytology and the Diagnostic Usefulness of Galectin-3 Immunostaining for the Follicular Variant of Papillary Thyroid Carcinoma  

Jung, Chan-Kwon (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Shin, Jung-Ha (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Lee, Hyun-Seung (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Lee, Ah-Won (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Jung, Eun-Sun (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Choi, Yeong-Jin (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Lee, Kyo-Young (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea)
Publication Information
The Korean Journal of Cytopathology / v.19, no.2, 2008 , pp. 160-163 More about this Journal
Abstract
The cytologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) has become one of the common causes of false negative diagnoses when performing fine needle aspiration cytology (FNAC) of the thyroid gland. We retrospectively reviewed all the aspirates for which a diagnosis of FVPTC had been made based on the surgically excised specimens, regardless of the cytologic diagnosis. 145 FNACs was performed in 135 patients. The cytologic diagnoses were categorized as 2 unsatisfactory specimens (1.4%), 16 benign (11.0%), 49 atypical (33.8%) and 78 malignant lesions (53.8%). The tumor cells consistently showed significant nuclear overlapping, irregular nuclei and fine chromatin in all cases; however, nuclear grooves and inclusions were scarce. Galectin-3 immunostaining was performed on the cell blocks of 65 cases and this was positive for 45 cases (69.2%). The results of our study demonstrate that the determination of minimal cytologic criteria is needed to raise the sensitivity of detecting FVPTC by FNAC, and galectin-3 immunostaining is useful to make decisions on the surgical treatment of cytologically atypical thyroid nodules.
Keywords
Fine needle aspiration; Thyroid cytology; Follicular variant of papillary thyroid carcinoma; Galectin-3;
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Times Cited By KSCI : 3  (Citation Analysis)
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