Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Garlic Extract on the Activation Pattern of MAPK Signaling in the Rat Heart After a Bout Exercise

마늘추출물이 운동부하 흰쥐의 심장내 MAPK signaling 활성에 미치는 영향

  • Lee, Jun-Hyuk (Chemistry and Biotechnology Examinations Bureau, Korean Intellectual Property Office) ;
  • Chung, Kyung-Tae (Department of Biomedical Laboratory Science, College of Natural Science) ;
  • Lee, Yang-Tae (Department of Physiology, College of Oriental Medicine, Dong-Eui University) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
  • Choi, Byung-Tae (School of Oriental Medicine, Pusan National University)
  • 이준혁 (특허청 화학생명공학심사국) ;
  • 정경태 (동의대학교 자연과학대학 임상병리학과) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 최병태 (부산대학교 한의학전문대학원)
  • Published : 2008.10.25
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Abstract

Since exercise training induces mechanical stress to the heart, we examined the activation pattern of mitogen-activated protein kinase(MAPK)s signaling pathway by immunohistochemistry. The immunoreactions of MAPKs signaling with c-fos and Schiff's reaction were increased in the cardiac muscle of exercised rat compared to normal one except immunoreaction for MEK1/2 and ERK1/2 and p38. However, the immunoreaction of phospho-JNK and phospho-p38 with early gene c-fos were arrested markedly in water extract of Alliium sativum (WEAS) treated rat compared to exercised one. Since MAPKs signaling does play a protective role in response to pathological stimulus in the heart, results in the present study suggest that WEAS may act as a alleviating agent for exercise-induced stress to. heart through regulating MAPKs signaling activation.

Keywords

References

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