Journal of Pharmaceutical Investigation

  • 제38권5호
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  • Pages.325-329
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  • 2008
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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In vivo Skin Deposition and Photoprotection Effect of Genistein in Liposomal Gel Formulations

  • Kim, Yong-Min (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Kim, Bo-Gyun (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Kang, Myung-Joo (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Eum, Jae-Yoon (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Choi, Young-Wook (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
  • 발행 : 2008.10.20
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초록

To enhance the skin delivery of genistein (GT), a soybean isoflavone having anti oxidative activity, comparative formulation studies including liposomes were carried out. GT-loaded conventional and elastic liposomal gel showed the enhanced skin deposition and photoprotection effect as well, in comparison to GT suspension. Elastic liposomes composed of soybean phosphatidylcholine and sodium deoxycholate (85:15, w/w%) were superior to conventional liposomes and were of characteristics as follows: about 130 nm in size; 85% encapsulation efficiency of GT; 5.8% skin deposition of applied dose; 40% inhibition effect on UVB-induced $H_2O_2$ production. Photoprotection effect was closely related to skin deposition of GT. In conclusion, it is possible to suggest that elastic liposomes could be a promising nanocarrier system for efficient skin delivery.

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참고문헌

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