[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4333/KPS.2008.38.5.325

In vivo Skin Deposition and Photoprotection Effect of Genistein in Liposomal Gel Formulations

Kim, Yong-Min (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
Kim, Bo-Gyun (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
Kang, Myung-Joo (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
Eum, Jae-Yoon (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
Choi, Young-Wook (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)

Publication Information

Journal of Pharmaceutical Investigation / v.38, no.5, 2008 , pp. 325-329 More about this Journal

Abstract

To enhance the skin delivery of genistein (GT), a soybean isoflavone having anti oxidative activity, comparative formulation studies including liposomes were carried out. GT-loaded conventional and elastic liposomal gel showed the enhanced skin deposition and photoprotection effect as well, in comparison to GT suspension. Elastic liposomes composed of soybean phosphatidylcholine and sodium deoxycholate (85:15, w/w%) were superior to conventional liposomes and were of characteristics as follows: about 130 nm in size; 85% encapsulation efficiency of GT; 5.8% skin deposition of applied dose; 40% inhibition effect on UVB-induced $H_2O_2$ production. Photoprotection effect was closely related to skin deposition of GT. In conclusion, it is possible to suggest that elastic liposomes could be a promising nanocarrier system for efficient skin delivery.

Keywords

Genistein; Skin delivery; Elastic liposome; Photoprotection; Antioxidative activity;

Citations & Related Records

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