Journal of Pharmaceutical Investigation

  • 제38권5호
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  • Pages.319-323
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  • 2008
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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Transdermal Delivery of Ceramide Using Sodium Deoxycholate-based Deformable Liposomes

  • Kim, Dong-Chan (School of Life Sciences and Biotechnology, Korea University) ;
  • Noh, Sang-Myoung (School of Life Science and Biotechnology, Pochon CHA University) ;
  • Kim, Young-Bong (Department of Animal Biotechnology, Konkuk University) ;
  • Baek, Kwang-Hyun (School of Life Science and Biotechnology, Pochon CHA University) ;
  • Oh, Yu-Kyoung (School of Life Sciences and Biotechnology, Korea University)
  • 발행 : 2008.10.20
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초록

For transdermal delivery of ceramides, various liposomes formulations were studied and evaluated. Sodium deoxycholate (SDC), Tween 20 and Span 85 were used as edge activators. The skin permeation of ceramides was performed using a Franz cell apparatus with hairless mouse skin. Among edge activators, SDC showed the higher values of deformability index and skin permeation than did others. For optimization of formulations, we varied the ratios of lipids to edge activators and the compositions between phosphatidylcholine (PC) and ceramides. The optimal ratio of lipid to SDC was observed to be 6:1 (w:w) and that of PC and ceramide was 1:1. Our results suggest that the skin permeation of ceramides could be enhanced by optimized deformable formulations of liposomes containing SDC as a major edge activator.

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