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http://dx.doi.org/10.4333/KPS.2008.38.5.319

Transdermal Delivery of Ceramide Using Sodium Deoxycholate-based Deformable Liposomes  

Kim, Dong-Chan (School of Life Sciences and Biotechnology, Korea University)
Noh, Sang-Myoung (School of Life Science and Biotechnology, Pochon CHA University)
Kim, Young-Bong (Department of Animal Biotechnology, Konkuk University)
Baek, Kwang-Hyun (School of Life Science and Biotechnology, Pochon CHA University)
Oh, Yu-Kyoung (School of Life Sciences and Biotechnology, Korea University)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.5, 2008 , pp. 319-323 More about this Journal
Abstract
For transdermal delivery of ceramides, various liposomes formulations were studied and evaluated. Sodium deoxycholate (SDC), Tween 20 and Span 85 were used as edge activators. The skin permeation of ceramides was performed using a Franz cell apparatus with hairless mouse skin. Among edge activators, SDC showed the higher values of deformability index and skin permeation than did others. For optimization of formulations, we varied the ratios of lipids to edge activators and the compositions between phosphatidylcholine (PC) and ceramides. The optimal ratio of lipid to SDC was observed to be 6:1 (w:w) and that of PC and ceramide was 1:1. Our results suggest that the skin permeation of ceramides could be enhanced by optimized deformable formulations of liposomes containing SDC as a major edge activator.
Keywords
Ceramide; Deformable liposomes; Sodium deoxycholate; Transdermal drug delivery;
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Times Cited By KSCI : 1  (Citation Analysis)
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