Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect on Melanogenesis of Ponciri Fructus Ethanol Extract

지실(枳實) 에탄올추출물의 멜라닌 형성 억제효과

  • Ko, Joon-Suk (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Lee, Jang-Cheon (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Jang, Yeong-Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim, Kyu-Sang (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Young-Cheol (Department of Herbology, College of Oriental Medicine, Sangji University)
  • 고준석 (상지대학교 한의과대학 본초학교실) ;
  • 이장천 (상지대학교 한의과대학 본초학교실) ;
  • 장영미 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 임규상 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이영철 (상지대학교 한의과대학 본초학교실)
  • Published : 2008.08.25
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Abstract

This study was to investigate the effect of Ponciri Fructus ethanol extract on the melanogenesis. The Ponciri Fructus markedly decreased melanin contents of B16F10 cells at a dose of $80{\mu}g/m{\ell}$. It was observed that the color of cell pellets was totally whitened compared with the control. The treatment of Ponciri Fructus inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. Regarding protein levels of the melanogenic enzymes, the Ponciri Fructus dose-dependently decreased tyrosinase and TRP-1 protein levels, and tyrosinase and TRP-1 were detected in similar manner. These results suggest that the Ponciri Fructus ethanol extract exerts its depigmenting effects through the suppression of tyrosinase and TRP-1.

Keywords

References

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