Economic Evaluation of Gemcitabine-cisplatin Chemotherapy for Non Small-Cell Lung Cancer Patient in an Outpatient Setting

비용-효과 분석 기법을 이용한 Gemcitabine 외래 항암 치료의 경제성 평가

  • Min, Su-Hyun (Department of Nursing, Inha University) ;
  • Ko, Su-Kyoung (Department of Nursing, Inha University, Outcomes Research, Pfizer Korea) ;
  • Lim, Ji-Young (Department of Nursing, Inha University)
  • 민수현 (인하대학교 간호학과) ;
  • 고수경 (인하대학교 간호학과, 한국화이자 제약 Outcomes Research) ;
  • 임지영 (인하대 간호학과)
  • Published : 2008.06.30

Abstract

Purpose: This analysis was conducted to evaluate the cost-effectiveness of gemcitabine-cisplatin chemotherapy for non small-cell lung cancer patients in an outpatient setting compared with the traditional inpatient setting. Methods: A cost-effective analysis was conducted from a societal perspective. The effects of treatment, which was measured as an adverse event rate, were abstracted from a published literature search and empirical data from one university hospital. The costs included both direct and indirect costs. Direct costs included hospitalizations, outpatient visits, and lab tests. Pharmaceutical costs were excluded in analysis because they were same for both options. Indirect costs included productivity loss of patients as well as care-givers. In order to determine the robustness of the results, sensitivity analysis on treatment protocol was conducted. Results: Literature search showed no difference in adverse effect rates between inpatient treatment protocol and outpatient treatment protocol. Therefore, this analysis is a cost-minimization analysis. Cost-savings in the outpatient setting was 555,936 won for one treatment cycle. Our sensitivity analysis indicated that the outpatient chemotherapy still showed cost-savings, regardless of changes in treatment protocol. Conclusion: The outpatient gemcitabine-cisplatin chemotherapy for non small-cell lung cancer resulted in cost savings compared to inpatient chemotherapy. More importantly, outpatient chemotherapy could improve the utilization of health service resources in terms of available beds.

Keywords

References

  1. Abratt, R. P., Bezwoda, W. R., Falkson, G., Goedhals, L., Hacking, D., & Rugg, T. A. (1994). Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A phase II study. Journal of Clinical Oncology, 12, 1535-1540 https://doi.org/10.1200/JCO.1994.12.8.1535
  2. Anderson, H., Lund, B., Bach, F., Thatcher, N., Walling, J., & Hansen, H. H. (1994). Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A Phase II study. Journal of Clinical Oncology, 12, 1821-1826 https://doi.org/10.1200/JCO.1994.12.9.1821
  3. Bischoff, H. G., Eberhardt, W., Wilke, H., & Gatzemeier, U. (1995). Experiences with gemcitabine in advanced non-small-cell lung cancer (NSCLC): Report of a phase - 1 dose - finding study of gemcitabine and ifosphamide. Canadian Journal of Infectious Disease, 6, 89
  4. Chang, H. J., Ahn, J. B., Lee, J. G., Shim, K. Y., Rha, S. Y., Kim, S. K., et al. (1999). Efficacy of gemcitabine chemotherpy in advanced Non- Small-Cell Lung Cancer (NSCLC): A phase 2 study. Journal of Korean Cancer Association, 31, 523-533
  5. Holmes, S. (1991). The oral complications of specific anti-cancer therapy. International Journal of Nursing Studies, 28, 343-360 https://doi.org/10.1016/0020-7489(91)90061-7
  6. Kim, S. K. (2004). Cost of non-small-cell lung cancer, Dailymedi. Retrieved October 20, 2006, from http://www.dailymedi.com/news/opdb/index.php?cmd=view&dbt=article&code=41040&page=2&sel=ticon&key=¡TM⁄&cate=&rgn=&term
  7. Kim, S. J., Yi, M. S., Eun, Y., Ko, M. H., Kim, J. H., Kim, D. O., et al. (2006). Role-identity of home care nurse practitioners. Journal of Korean Academy of Nursing, 36, 103-113 https://doi.org/10.4040/jkan.2006.36.1.103
  8. Korea National Statistical Office. (2006). Cause of death statistics. Retrieved October 20, 2006, from http://www.kosis.kr
  9. Ministry of Health & Welfare. (2006). Annual report of the Korea central cancer registry. Retrieved October 20, 2006, from http://www.mw.go.kr/user.tdf
  10. Ministry of Labor (2006). Survey report on wage structure. Retrieved October 20, 2006, from http://www.molab.go.kr
  11. Oh, K., Kim, M. J., Kim, K. S., Park, J. W., Sung, M. S., Oh, E. G., et al. (2007). Educational issues and strategies to improve APN education. Journal of Korean Academy of Nursing, 37, 801-809 https://doi.org/10.4040/jkan.2007.37.5.801
  12. Park, H. J., & Shin, H. S. (1995). The effects of mouth care with sterile normal saline on chemotherapy-induced stomatitis. Journal of Korean Academy of Nursing, 25, 5-16
  13. Rice, D. (1967). Estimating the cost of illness. American Journal of Public Health, 57, 424-440 https://doi.org/10.2105/AJPH.57.3.424
  14. Yang, B. M. (1999). Health economics. Seoul: Nanamsinseo