Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Histomorphometric evaluation of bone healing with fully interconnected microporous biphasic calcium phosphate ceramics in rabbit calvarial defects

삼차원적으로 연결된 미세다공성 구조를 가진 이상인산칼슘 골이식재의 골치유에 관한 조직계측학적 평가

  • Lee, Jong-Sik (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Choi, Seok-Kyu (Megagen Implant Co., Ltd) ;
  • Ryoo, Gyeong-Ho (Megagen Implant Co., Ltd) ;
  • Park, Kwang-Bum (Megagen Implant Co., Ltd) ;
  • Jang, Je-Hee (Department of Periodontology, Graduate School of Dentistry, Kyungpook National University) ;
  • Lee, Jae-Mok (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Suh, Jo-Young (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Park, Jin-Woo (Department of Periodontology, School of Dentistry, Kyungpook National University)
  • 이종식 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 최석규 ((주)메가젠 임플란트) ;
  • 류경호 ((주)메가젠 임플란트) ;
  • 박광범 ((주)메가젠 임플란트) ;
  • 장제희 (경북대학교 대학원 치의학과 치주과학교실) ;
  • 이재목 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 서조영 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 박진우 (경북대학교 치의학전문대학원 치주과학교실)
  • Published : 2008.06.30
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Abstract

Purpose: The purpose of this study was to histomorphometrically evaluate the osteoconductivity of a new biphasic calcium phosphate ceramics with fully interconnected microporous structure. Material and Methods: Osseous defects created in the rabbit calvaria were filled with four different bone graft substitutes. Experimental sites were filled with a new fully interconnected microporous biphasic calcium phosphate with(BCP-2) or without(BCP-1) internal macropore of $4400\;{\mu}m$ in diameter. MBCP(Biomatlante, France) and Bio-Oss(Geistlich Pharma, Switzerland) were used as controls in this study. Histomorphometric evaluation was performed at 4 and 8 weeks after surgery. Result: In histologic evaluation, new bone formation and direct bony contact with the graft particles were observed in all four groups. At 4 weeks, BCP-1(15.5%) and BCP-2(15.5%) groups showed greater amount of newly formed mineralized bone area(NB%) compared to BO(11.4%) and MBCP(10.3%) groups. The amounts of NB% at 8 weeks were greater than those of 4 weeks in all four groups, but there was no statistically significant differences in NB% between the groups. Conclusion: These results indicate that new bone substitutes, BCP with interconnected microporous structure and with or without internal macroporous structures, have the osteoconductivity comparable to those of commercially available bone substitutes, MBCP and Bio-Oss.

Keywords

References

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