Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Involvement of pCREB Expression in Inhibitory Effects of Coptis japonica on Morphine-induced Psychological Dependence

  • Kwon, Seung-Hwan (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Ha, Ri-Ra (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Seok-Yong (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2008.06.30
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Abstract

Morphine is a potent analgesic with significant abuse potential, because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. Previously, we have reported the inhibitory effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. The present study was employed whether p-CREB expression is involved in the inhibitory effect of MCJ on the morphine-induced CPP in the mouse hippocampus. Repeated administration of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of p-CREB was increased in the dentate gyrus of the hippocampus that had undergone morphineinduced CPP. This increase of expression was significantly inhibited by administration of MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of p-CREB expression in the mouse dentate gyrus of the hippocampus.

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References

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