Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

  • Choi, Ji-Young (Uimyung Institute for Neuroscience, Sahmyook University) ;
  • Pena, Ike Dela (Uimyung Institute for Neuroscience, Sahmyook University) ;
  • Choi, Jong-Hyun (Uimyung Institute for Neuroscience, Sahmyook University) ;
  • Yoon, Seo-Young (Uimyung Institute for Neuroscience, Sahmyook University) ;
  • Yim, Dong-Sool (Uimyung Institute for Neuroscience, Sahmyook University) ;
  • Lee, Yong-Soo (Department of Pharmacology, College of Pharmacy, Duksung Women's University) ;
  • Ko, Kwang-Ho (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
  • Shin, Chan-Young (Department of Pharmacology, College of Medicine, Konkuk University) ;
  • Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Kim, Won-Ki (Department of Neuoscience, College of Medicine, Korea University) ;
  • Cheong, Jae-Hoon (Uimyung Institute for Neuroscience, Sahmyook University)
  • Published : 2008.06.30
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Abstract

Gardenia jasminoides (G. jasminoides) is traditionally used to treat insomnia, jaundice, emotional disorders, hepatic disease, and inflammatory disease. Previously, we found that geniposide and the water extract of G. jasminoides increased $Cl^-$ influx in neuroblastoma. Here we examined the sychopharmacological activities of G. jasminoides and its constituents. G. jasminoides extract was orally administered at 100 and 200 mg/kg, and genipin and geniposide were intraperitoneally injected at 2, 10, and 20 mg/kg. G. jasminoides extract (200 mg/kg) significantly decreased total open field activity but increased rearing activity in the center of the open field, suggesting an increase in exploratory activity. Genipin and geniposide did not change open field activity, but geniposide (20 mg/kg) increased rearing activity in the central area. The extract (200 mg/kg) significantly decreased rotarod and wire-balancing activity, but genipin and geniposide did not. No compounds influenced thiopental-induced sleeping or electroshock-induced seizures. The extract (200 mg/kg) significantly increased staying time in the open arms of the elevated plus maze and the entry ratio into the open arms, and geniposide (20 mg/kg) also increased open arm entry. Electroshock stress decreased open arm activity, but the extract and geniposide (20 mg/kg) significantly reversed that effect. This results indicate that G. jasminoides extract and geniposide alleviated anxiety with greater efficacy in stressed animals than normal animals.

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References

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