Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Synthesis of New pH-Sensitive Poly(ethylene oxide-b-maleic acid) from Modification of Poly(ethylene oxide-b-N-phenylmaleimide)

  • Go, Da-Hyeon (Department of Chemistry, Kyunghee University) ;
  • Jeon, Hee-Jeong (Department of Chemistry, Kyunghee University) ;
  • Kim, Tae-Hwan (Department of Chemistry, Kyunghee University) ;
  • Kim, Geun-Seok (Department of Chemistry, Kyunghee University) ;
  • Choi, Jin-Hee (Department of Chemistry, Kyunghee University) ;
  • Lee, Jae-Yeol (Department of Chemistry, Kyunghee University) ;
  • Kim, Jung-Ahn (Department of Chemistry, Kyunghee University) ;
  • Yoo, Hyun-Oh (Department of Chemical Engineering, Hanyang University) ;
  • Bae, You-Han (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah)
  • Published : 2008.10.31
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Abstract

A new and useful poly(ethylene oxide)-based pH-sensitive block copolymer is introduced. Poly(ethylene oxide-b-N-phenylmaleimide) was first synthesized by anionic polymerization of N-phenylmaleimide (N-PMI) using mixed alkali metal polymeric alkoxide by sequential monomer addition method in the mixture of benzene/THF/DMSO (10/5/3, v/v/v) at room temperature. Reductive deimidation of the resulting block copolymer was performed using hydrazine monohydrate leading to the formation of the corresponding pH-sensitive poly(ethylene oxide-b-maleic acid).

Keywords

References

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