Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Anti-inflammatory Effect Of Extracts from Cheongmoknosang(Morus alba L.) in Lipopolysaccharide-stimulated Raw Cells

청목노상 (Morus alba L.)추출물에 의한 Lipopolysaccharide로 유도된 Raw 246.7 cell에서 염증 억제효과

  • Cho, Young-Je (Department of Food Engineering, Kyungpook National University) ;
  • An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
  • 조영제 (경북대학교 식품공학과) ;
  • 안봉전 (대구한의대학교 화장품약리학과)
  • Published : 2008.03.31
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Abstract

With extracts from Cheongmoknosang, anti-inflammatory effect was examined in LPS-stimulated Raw 264.7 cells. LPS (10 ng/ml) treatment increased the production of inflammatory cytokines, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ but the ethanol extracts from Cheongmoknosang slightly decreased the production of $TNF-{\alpha}$ and also reduced the expression of iNOS and the production of COX-2. It seems that anti-inflammatory effects of ethanol extracts from Cheongmoknosang is partly due to the inhibition of iNOS and COX-2 expression by inhibiting nuclear translocation of $NF-{\kappa}B$ and AP-l in Raw 264.7 cells.

108종의 뽕잎 중 청목노상추출물에 의한 LPS로 염증을 유발한 Raw 264.7 세포에서 항염증 효과를 측정한 결과, 청목노상 에탄올추출물 자체는 염증반응에 관여하지 않았으며, 청목노상 에탄올추출물이 LPS 처리에 의해 증가된 염증관련 NO, iNOS, COX-2의 발현을 억제하고, $TNF-{\alpha}$의 생성을 억제함으로서 항염증 효과가 있음이 확인되었다.

Keywords

References

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