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Anti-inflammatory Effect Of Extracts from Cheongmoknosang(Morus alba L.) in Lipopolysaccharide-stimulated Raw Cells  

Cho, Young-Je (Department of Food Engineering, Kyungpook National University)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Applied Biological Chemistry / v.51, no.1, 2008 , pp. 44-48 More about this Journal
Abstract
With extracts from Cheongmoknosang, anti-inflammatory effect was examined in LPS-stimulated Raw 264.7 cells. LPS (10 ng/ml) treatment increased the production of inflammatory cytokines, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ but the ethanol extracts from Cheongmoknosang slightly decreased the production of $TNF-{\alpha}$ and also reduced the expression of iNOS and the production of COX-2. It seems that anti-inflammatory effects of ethanol extracts from Cheongmoknosang is partly due to the inhibition of iNOS and COX-2 expression by inhibiting nuclear translocation of $NF-{\kappa}B$ and AP-l in Raw 264.7 cells.
Keywords
anti-inflammatory; Cheongmoknosang leaves; effectextracts;
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