Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Effect of ivermectin and doramectin for larval(Anisakis spp) migratory inhibition in rats

랫드에서 아니사키스 유충에 대한 이버멕틴과 도라멕틴의 운동성 억제효과

  • Lee, Seung-Hwan (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Jee, Cha-Ho (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University)
  • 이승환 (충북대학교 수의과대학 수의학과) ;
  • 지차호 (충북대학교 수의과대학 수의학과)
  • Published : 2008.03.30
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Abstract

This experiment has been investigated in order to examine the effect of ivermectin and doramectin for laval migratory inhibition in rats. Anisakis spp larvae were obtained from the mackerels in fish market in Cheongju. A total of 225 rats were classified with 3 groups with the same number ($3{\times}75$ rats); group I was control divided into 3 subgroups including 25 rats in each one, others (test groups) were treated subcutaneously with ivermectin and doramectin by 3 kinds of concentrations ($200{\mu}g/kg$, 400, 800), respectively. At 15 minutes after treating, 10 larvae were taken orally into each rat of 6 subgroups in test, and 5 rats were necropsied at 0.5, 1, 2, 4 and 8 hours after oral administration. The recovered larvae were used in larval migration inhibition (LMI). Ivermectin is significantly more effective than doramectin. In rats, the inhibitory effect of ivermectin and doramectin is slightly less than in vitro.

Keywords

References

  1. Papich MG. 2002. Saunders handbook of veterinary drugs. Saunders, North Carolina: 180
  2. Van Thiel PH, Kuipers FC, Roskam RT. 1960. A nematode parasitic to herring, causing acute abdominal syndromes in man. Trop Geogr Med 2 : 97-113
  3. Smith JW, Wootten R. 1978. Anisakis and anisakiasis. Adv Parasitol 16 : 93-163 https://doi.org/10.1016/S0065-308X(08)60573-4
  4. Besprozvannykh VV, Ermolenko AV, Kammer VD. 2004. Peter- the Great Gulf fishes are a source of human invasion of the nematode Anisakis simplex (the family Anisakidae): Med Parazitol (Mosk) 3: 21-24
  5. Koyama T. 1982. Clinical, epidemiological and morphological studies on 150 cases of acute gastric anisakiasis in Fukuoda prefecture. Jpn J Parasitol 33 : 73-92
  6. Lopez-Serrano MC, Gomez AA, Daschner A, et al. 2000. Gastroallergic anisakiasis: Findings in 22 patients. J Castro Hepetol 15: 503-506 https://doi.org/10.1046/j.1440-1746.2000.02153.x
  7. Pampiglion S, Rivasi F, Criscuolo M, et al. 2002. Human anisakiasis in Italy a report of eleven new cases. Pathol Res Pract 198: 429-434 https://doi.org/10.1078/0344-0338-00277
  8. Skimisson K. 2006. Pseudoterranova decipiens (Nematoda, Anisakidae) larvae reported from human in Iceland after consumption of insufficiently cooked fish. Laeknabladid 92 : 21-25
  9. Kim CH, Chung BS, Moon YI, et al. 1971. A case report on human infection with Anisakis sp. Korean J Parasitol 9 : 39-43 https://doi.org/10.3347/kjp.1971.9.1.39
  10. Cho SY, Chi JG, Kim IS. 1980. A case human anisakiasis in Korea. Seoul Med 21: 203-208
  11. Im KI, Yong TS, Shin HJ, et al. 1990. Gastric anisakiasis in Korea. Yonsei Rep Trop Med 21 : 1-7
  12. Jin SJ, Suk DS. 1984. A case of human gastric anisakiasis in Korea. Inje Med J 5: 359-363 https://doi.org/10.1002/ajim.4700050504
  13. 전재형, 지차호. 2007. 시험관내에서 이버멕틴, 도라멕틴, 에타놀에 대한 아니키스 유충의 운동성 억제효과. 대한수의학회지 47(2) : 197-202
  14. Burg RM, Miller BM, Baker EE. 1979. Avermectin, a new family of potent anthelmintic agent: Producing organism and fermentation. Antimicrob Agents Chemother 15: 361-372 https://doi.org/10.1128/AAC.15.3.361
  15. 류판동, 최진규, 이문한. 1990. IVM의 임상약리학. 대한수의학회지 30: 588-591
  16. Cambell WC, Fisher MH, Stapley EO. 1983. Ivermectin: A potent new antiparasitic agent. Science 221: 823-828 https://doi.org/10.1126/science.6308762
  17. Douch PGC, Morum PE. 1994. The effect of anthelmintics on ovine larval nematode parasite migration in vitro. Int J Parasitol 24 : 321-326 https://doi.org/10.1016/0020-7519(94)90078-7
  18. Wagland BM, Jones WO, Hribar L, et al. 1992. A new simplified assay for larval migration inhibition. Int J Parasitol 22: 1183-1185 https://doi.org/10.1016/0020-7519(92)90040-R
  19. Douch PGC, Harrison GBL, Buchanan LL, et al. 1983. In vitro bioassay of sheep gastrointestinal mucus for nematode paralysing activity mediated by substances with some properties characteristic of SRS-A. Int J Parasitol 13: 207-212 https://doi.org/10.1016/0020-7519(83)90014-0
  20. Jones WO, Emery DL, Mcclure SJ, et al. 1994. Changes in inflammation mediators and larval inhibitory activity in intestinal contents and mucus during primary and challenge infections of sheep with Trichostrongylus colubriiormis. lnt J Parasitol 24: 519-525 https://doi.org/10.1016/0020-7519(94)90143-0