Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Transdermal Permeation Behavior of 5-FU using Microneedle

마이크로니들을 이용한 5-FU의 경피투과 거동

  • Kim, Myoung-Jin (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Park, Jung-Soo (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Kim, Yun-Tae (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Lee, Jun-Hee (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Ahn, Sik-Il (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Park, Jong-Hak (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Mo, Jong-Hyun (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Lee, Tae-Wan (Research Center, Daehwa Pharm. Co. Ltd.) ;
  • Lee, Han-Koo (Research Center, Daehwa Pharm. Co. Ltd.) ;
  • Khang, Gil-Son (BK-21 Polymer BIN Fusion research Team, Chonbuk National University) ;
  • Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
  • 김명진 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 박정수 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 김윤태 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 이준희 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 안식일 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 박종학 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 모종현 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 이태완 (㈜대화제약 중앙연구소) ;
  • 이한구 (㈜대화제약 중앙연구소) ;
  • 강길선 (전북대학교 BK-21 고분자 BIN융합연구팀) ;
  • 이해방 (한국화학연구원 나노생체재료연구팀)
  • Published : 2008.02.21
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Abstract

5-Fluorouracil (5-FU) is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time and strong side effects. Microneedle introduced to find a solution of problems. Microneedle device with roll was manufactured for transdermal delivery of various drugs. 5-FU was mixed in non-ionic surfactant such as tween 20 and tween 80. Camscope was used to analysis the permeation magnitude of treated skin by microneedle and trypan blue staining. The 5-FU solution with surfactant measured by ZETA-potential analysis system for stability of solution. The skin permeation rate of 5-FU determined by HPLC. We confirmed that cross treated skin was dyed more deeply than parallel treated skin through trypan blue staining. The results indicate that skin permeation rate of 5-FU was increased with the treatment types and treatment times.

Keywords

References

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