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http://dx.doi.org/10.4333/KPS.2008.38.1.045

Transdermal Permeation Behavior of 5-FU using Microneedle  

Kim, Myoung-Jin (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Park, Jung-Soo (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Kim, Yun-Tae (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Lee, Jun-Hee (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Ahn, Sik-Il (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Park, Jong-Hak (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Mo, Jong-Hyun (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Lee, Tae-Wan (Research Center, Daehwa Pharm. Co. Ltd.)
Lee, Han-Koo (Research Center, Daehwa Pharm. Co. Ltd.)
Khang, Gil-Son (BK-21 Polymer BIN Fusion research Team, Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.1, 2008 , pp. 45-50 More about this Journal
Abstract
5-Fluorouracil (5-FU) is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time and strong side effects. Microneedle introduced to find a solution of problems. Microneedle device with roll was manufactured for transdermal delivery of various drugs. 5-FU was mixed in non-ionic surfactant such as tween 20 and tween 80. Camscope was used to analysis the permeation magnitude of treated skin by microneedle and trypan blue staining. The 5-FU solution with surfactant measured by ZETA-potential analysis system for stability of solution. The skin permeation rate of 5-FU determined by HPLC. We confirmed that cross treated skin was dyed more deeply than parallel treated skin through trypan blue staining. The results indicate that skin permeation rate of 5-FU was increased with the treatment types and treatment times.
Keywords
Transdermal; 5-FU; Tween 20; Tween 80; Microneedle;
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Times Cited By KSCI : 3  (Citation Analysis)
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