Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Micronucleus Test of PolycanTM, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice

  • Lee, Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Cho, Hyung-Rae (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Yang, Kun-Ju (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Moon, Seung-Bae (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Park, Bok-Ryeon (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Shin, Hyun-Dong (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Jang, Hee-Jeong (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Kim, Lin-Su (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University)
  • Published : 2008.03.31
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Abstract

In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that $Polycan^{TM}$ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of $Polycan^{TM}$ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.

Keywords

References

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