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http://dx.doi.org/10.5487/TR.2008.24.1.011

Micronucleus Test of PolycanTM, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice  

Lee, Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University)
Cho, Hyung-Rae (Glucan Corp. Research Institute, Marine Biotechnology Center)
Yang, Kun-Ju (Glucan Corp. Research Institute, Marine Biotechnology Center)
Moon, Seung-Bae (Glucan Corp. Research Institute, Marine Biotechnology Center)
Park, Bok-Ryeon (Glucan Corp. Research Institute, Marine Biotechnology Center)
Shin, Hyun-Dong (Glucan Corp. Research Institute, Marine Biotechnology Center)
Jang, Hee-Jeong (Glucan Corp. Research Institute, Marine Biotechnology Center)
Kim, Lin-Su (Glucan Corp. Research Institute, Marine Biotechnology Center)
Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University)
Publication Information
Toxicological Research / v.24, no.1, 2008 , pp. 11-15 More about this Journal
Abstract
In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that $Polycan^{TM}$ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of $Polycan^{TM}$ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
Keywords
$Polycan^{TM}$; ${\beta}$-Glucan; Micronucleus test; Genotoxicity; Mice;
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