Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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A case of granulomatous meningoencephalomyelitis in a dog

개의 육아종성 뇌수막척수염 증례 보고

  • Jung, Ji-Youl (College of Veterinary Medicine, Cheju National University) ;
  • Jo, Suk-Hee (College of Veterinary Medicine, Cheju National University) ;
  • Kang, Yoon-Ho (ShinJeju Animal Clinic) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine, Cheju National University)
  • Accepted : 2008.11.10
  • Published : 2008.12.30
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Abstract

Granulomatous meningoencephalomyelitis (GME) is a sporadic, idiopathic, non suppurative inflammatory disease of the canine central nervous system. GME appears to have a worldwide distribution and to occur mostly in young to middle-age dogs of small breeds. A 6-year-old female mixed dog with wry neck, ataxia and rolling was submitted to the Cheju National University for diagnosis. Grossly, in the brain, cerebrospinal fluid was mildly increased and dilatation of the subarachnoid blood vessels was observed. Histopathologically, the lesions were characterized by perivascular cuffs of lymphocytes, various numbers of macrophages and plasma cells in the brainstem and cerebral white matter. Numerous granuloma composed of lymphocytes and histiocytes were scattered throughout the brainstem. Two malacic foci characterized by axonal swelling and gitter cell infiltration with hemorrhage were noted in the medulla oblongata and cerebellum. Special stains failed to demonstrate any infectious agents. Immunohistochemically, the infiltrated cells demonstrated strong positive reactions for CD3, a marker for T lymphocytes origin. Based on the clinical signs, histopathology, and immunohistochemistry, this case was diagnosed as GME in a mixed dog.

Keywords

References

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