Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Transdermal Permeation Characteristics of Anti Cholesterol Ointment using Nicotinic acid N-oxide

Nicotinic acid N-oxide를 이용한 항콜레스테롤 연고의 경피 투과 특성

  • 정덕채 (시립인천대학교 자연과학대학 화학과) ;
  • 김규원 (시립인천대학교 자연과학대학 화학과)
  • Published : 2008.06.30
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Abstract

Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as Nicotinic acid N-oxide in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.

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