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http://dx.doi.org/10.12925/jkocs.2008.25.2.2

Transdermal Permeation Characteristics of Anti Cholesterol Ointment using Nicotinic acid N-oxide  

Jung, Duck-Chae (Department of Chemistry, University of Incheon)
Kim, Kyu-Won (Department of Chemistry, University of Incheon)
Publication Information
Journal of the Korean Applied Science and Technology / v.25, no.2, 2008 , pp. 123-129 More about this Journal
Abstract
Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as Nicotinic acid N-oxide in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.
Keywords
Transdermal therapeutic system; Nicotinic acid N-oxide; skin permeation rate antihyperlipoproteinemic agent;
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Times Cited By KSCI : 1  (Citation Analysis)
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