Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant and Anti-inflammatory Activities of Equisetum hyemale

  • Park, Eun-Young (Department of Rehabilitation, College of Alternative Medicine, Jeonju University) ;
  • Jeon, Hoon (College of Pharmacy, Woosuk University)
  • Published : 2008.12.31
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Abstract

Equisetum hyemale L. has been prescribed widely as a traditional medicine for the treatment of inflammatory diseases such as rheumatoid arthritis, conjunctivitis, pyelonephritis. In order to identification the mechanism, we examined an antioxidant and anti-inflammatory activity of 85% methanol extract of E. hyemale. In this study E. hyemale exhibited strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, superoxide radical, and nitric oxide. To elucidate the anti-inflammatory properties of E. hyemale, we investigated the inhibition effects of nitric oxide and IL-6 by E. hyemale in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. E. hyemale suppressed nitric oxide, IL-6 production and iNOS expression dose-dependently without notable cytotoxic activity. These data suggest that E. hyemale might be useful in inflammatory diseases by inhibiting the free radicals and inflammatory mediators.

Keywords

References

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