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Antioxidant and Anti-inflammatory Activities of Equisetum hyemale  

Park, Eun-Young (Department of Rehabilitation, College of Alternative Medicine, Jeonju University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.14, no.4, 2008 , pp. 239-243 More about this Journal
Abstract
Equisetum hyemale L. has been prescribed widely as a traditional medicine for the treatment of inflammatory diseases such as rheumatoid arthritis, conjunctivitis, pyelonephritis. In order to identification the mechanism, we examined an antioxidant and anti-inflammatory activity of 85% methanol extract of E. hyemale. In this study E. hyemale exhibited strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, superoxide radical, and nitric oxide. To elucidate the anti-inflammatory properties of E. hyemale, we investigated the inhibition effects of nitric oxide and IL-6 by E. hyemale in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. E. hyemale suppressed nitric oxide, IL-6 production and iNOS expression dose-dependently without notable cytotoxic activity. These data suggest that E. hyemale might be useful in inflammatory diseases by inhibiting the free radicals and inflammatory mediators.
Keywords
Equisetum hyemale; Antioxidant; Anti-inflammatory;
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1 Bonomini, F., Tengattini, S., Fabiano, A., Bianchi, R., and Rezzani, R., Atherosclerosis and oxidative stress. Histol Histopathol. 23, 381-390 (2008)   PUBMED
2 Conner, E.M. and Grisham, M.B., Inflammation, free radicals, and antioxidants. Nutrition. 12, 274-277 (1996)   DOI   ScienceOn
3 D'Acquisto, F., May, M.J., and Ghosh, S., Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies. Mol. Interv. 2, 22-35 (2002)   DOI   ScienceOn
4 Milovanovi , V., Radulovi , N., Todorovi , Z., Stankovi , M., and Stojanovi , G., Antioxidant, antimicrobial and genotoxicity screening of hydro-alcoholic extracts of five serbian Equisetum species. Plant Foods Hum. Nutr. 62, 113-119 (2007)   DOI
5 Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (1983)   DOI   ScienceOn
6 Oh, H., Kim, D.H., Cho, J.H., and Kim, Y.C., Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J. Ethnopharmacol. 95, 421-424 (2004)   DOI   ScienceOn
7 Saha, K., Lajis, N.H., Israf, D.A., Hamzah, A.S., Khozirah, S., Khamis, S., and Syahida, A., Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants. J. Ethnopharmacol. 92, 263-267 (2004)   DOI   ScienceOn
8 Syrchina, A.I., Voronkov, M.G., Tyukavkina, N.A., and Babkin, V.A., Phenolic acids and flavonoids of sporogenous stems of Equisetum arvense. Khim. Prir. Soedin. 6, 803-804 (1978)
9 Watt, J.G., The price of factor VIII. Lancet. 2, 301 (1979)   PUBMED
10 Do Monte, F.H., dos Santos, JG. Jr., Russi, M., Lanziotti, V.M., Leal, L.K., Cunha, GM., Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of stems from Equisetum arvense L. in mice. Pharmacol. Res. 49, 239-243 (2004)   DOI   ScienceOn
11 Thiemermann, C. and Vane, J., Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur. J. Pharmacol. 182, 591-595 (1990)   DOI   ScienceOn
12 Hewett, J.A. and Roth, R.A., Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol. Rev. 45, 382-411 (1993)   PUBMED
13 Kaplan, M., Mutlu, E.A., Benson, M., Fields, J.Z., Banan, A., and Keshavarzian, A., Use of herbal preparations in the treatment of oxidant-mediated inflammatory disorders. Complement Ther. Med. 15, 207-216 (2007)   DOI   ScienceOn
14 Syrchina, A.I., Zapesochnaya, G.G., Tyukavkina, N.A., and Voronkov, M.G., Glycosides of Equisetum arvense flavones. Khim. Prir. Soedin. 3, 413-414 (1980)
15 Erridge, C., Bennett-Guerrero, E., and Poxton, I.R., Structure and function of lipopolysaccharides. Microbes Infect. 4, 837-851 (2002)   DOI   ScienceOn
16 Seo, W.G., Pae, H.O., Oh, G.S., Chai, K.Y., Kwon, T.O., Yun, Y.G., Kim, N.Y., and Chung, H.T., Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells. J. Ethnopharmacol. 76, 59-64 (2001)   DOI   ScienceOn
17 Ibrahim, H.R., Hoq, M.I., and Aoki, T., Ovotransferrin possesses SODlike superoxide anion scavenging activity that is promoted by copper and manganese binding. Int. J. Biol. Macromol. 41, 631-640 (2007)   DOI   ScienceOn
18 Halliwell, B., Free radicals, antioxidants, and human disease: curiosity, cause, or consequence. Lancet. 344, 721-724 (1994)   DOI   ScienceOn
19 Oka, M., Tachibana, M., Noda, K., Inoue, N., Tanaka, M., and Kuwabara, K., Relevance of anti-reactive oxygen species activity to antiinflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia. Phytomedicine 14, 465-472 (2007)   DOI   ScienceOn
20 Chen, Y.J., Hsu, K.W., Tssai, J.N., Hung, C.H., Kuo, T.C., and Chen, Y.L., Involvement of protein kinase C in the inhibition of lipopolysaccharide- induced nitiric oxide production by thapsigargin in RAW 264.7 macrophages. Int. J. Biochem. Cell Biol. 37, 2574-2585 (2005)   DOI   ScienceOn
21 Xu, C.F., Bian, X.Y., Qu, S.M., You, L.H., Qi, Z.M., Cheng, W., Liu, X.J., Liu, W.Z., and Ren, S.J., Effect of Equisetum hyemale on experimental hyperlipemia in rats and its toxic test. Zhongguo Zhong Yao Za Zhi 18, 52-53 (1993)   PUBMED
22 Lee, Y.S., Han, O.K., Park, C.W., Yang, C.H., Jeon, T.W., Yoo, W.K., Kim, S.H., and Kim, H.J., Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264.7 macrophage cells. J. Ethnopharmacol. 100, 289-294 (2005)   DOI   ScienceOn
23 Park, S.J., Lee, S.C., Hong, S.H., and Kim, H.M., Degradation of IkappaBalpha in activated RAW264.7 cells is blocked by the phosphatidylinositol 3-kinase inhibitor LY294002. Cell Biol. Toxicol. 18, 121-130 (2002)   DOI
24 Gyamfi, M.A., Yonamine, M., and Aniya, Y., Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries. Gen. Pharmacol. 32, 661-667 (1999)   DOI   ScienceOn
25 Takatsuto, S., Abe, H., and Gamoh, K., Evidence for brassino-steroids of Equisetum arvense L. Agric. Biol. Chem. 54, 1057-1059 (1990)
26 Cao, X.Y., Dong, M., Shen, J.Z., Wu, B.B., Wu, P.M., Du, X.D., Wang, Z., Qi, Y.T., and Li, B.Y., Tilmicosin and tylosin have antiinflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. Int. J. Antimicrob. Agents 27, 431-438 (2006)   DOI   ScienceOn
27 Rakel, D.P. and Rindfleisch, A., Inflammation: nutritional, botanical, and mind-body influences. South Med. J. 98, 303-310 (2005)   DOI   ScienceOn
28 Bertolini, A., Ottani, A., and Sandrini, M., Dual acting anti-inflammatory drugs: a reappraisal. Pharmacol. Res. 44, 437-450 (2001)   DOI   ScienceOn
29 D'Agostino, M., Dini, A., Pizza, C., Senatore, F., and Aquino, R., Sterols from Equisetum arvense. Boll-Soc. Ital. Biol. Sper. 60, 2241-2245 (1984)