Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Discovery and Synthesis of Novel N-Cyanopyrazolidine and N-Cyanohexahydropyridazine Derivatives as Cathepsin Inhibitors

  • Song, Jong- Hwan (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) ;
  • Kim, Sun-Gi (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology-) ;
  • No, Zae-Sung (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) ;
  • Hyun, Young-Lan (Crystalgenomics, Inc.) ;
  • Jeon, Dong-Ju (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) ;
  • Kim, Ik-Yon (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
  • Published : 2008.08.20
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Abstract

The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.

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References

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