Browse > Article
http://dx.doi.org/10.5012/bkcs.2008.29.8.1467

Discovery and Synthesis of Novel N-Cyanopyrazolidine and N-Cyanohexahydropyridazine Derivatives as Cathepsin Inhibitors  

Song, Jong- Hwan (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Kim, Sun-Gi (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology-)
No, Zae-Sung (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Hyun, Young-Lan (Crystalgenomics, Inc.)
Jeon, Dong-Ju (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Kim, Ik-Yon (Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.29, no.8, 2008 , pp. 1467-1471 More about this Journal
Abstract
The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.
Keywords
Cathepsins; Rheumatoid arthritis; N-Cyanopyrazolidine; N-Cyanohexahydropyridazine
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Drake, F. H.; Dodds, R. A.; James, I. A.; Connor, J. R.; Debouck, C.; Richardson, S.; Lee-Rykaczewski, L.; Coleman, L.; Riemann, D.; Barthlow, R.; Hastings, G.; Gowen, M. J. Biol. Chem. 1996, 271, 12511   DOI   ScienceOn
2 Gelb, B. D.; Shi, G.-P.; Chapman, H. A.; Desnick, R. J. Science 1996, 273, 1236   DOI   ScienceOn
3 Saftig, P.; Hunziker, E.; Wehmeyer, O.; Jones, S.; Boyde, A.; Rommerskirch, W.; Moritz, J. D.; Schu, P.; von Figura, K. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 13453
4 Boros, E. E.; Bouvier, F.; Randhawa, S.; Rabinowitz, M. H. J. Heterocycl. Chem. 2001, 38, 613   DOI   ScienceOn
5 Turk, V.; Turk, B.; Turk, D. EMBO J. 2001, 20, 4629   DOI   ScienceOn
6 Leung-Toung, R.; Li, W.; Tam, T. F.; Karimian, K. Curr. Med. Chem. 2002, 9, 979   DOI   ScienceOn
7 Bromme, D.; Okamoto, K. Biol. Chem. Hoppe-Seyler 1995, 376, 379   DOI   ScienceOn
8 Ahn, J. H.; Kim, J. A.; Kim, H.-M.; Kwon, H.-M.; Huh, S.-C.; Rhee, S. D.; Kim, K. R.; Yang, S.-D.; Park, S.-D.; Lee, J. M.; Kim, S. S.; Cheon, H. G. Bioorg. Med. Chem. Lett. 2005, 15, 1337   DOI   ScienceOn
9 Ahn, J. H.; Shin, M. S.; Jun, M. A.; Jung, S. H.; Kang, S. K.; Kim, K. R.; Rhee, S. D.; Kang, N. S.; Kim, S. Y.; Sohn, S.-K.; Kim, S. G.; Jin, M. S.; Lee, J. O.; Cheon, H. G.; Kim, S. S. Bioorg. Med. Chem. Lett. 2007, 17, 2622   DOI   ScienceOn
10 Trentham, D. E.; Townes, A. S.; Kang, A. H. J. Exp. Med. 1977, 146, 857   DOI   ScienceOn
11 Ma, D.; Zhang, Y.; Yao, J.; Wu, S.; Tao, F. J. Am. Chem. Soc. 1998, 120, 12459   DOI   ScienceOn
12 McGrath, M. E. Annu. Rev. Biophys. Biomol. Struct. 1999, 28, 181   DOI   ScienceOn
13 Lecaille, F.; Kaleta, J.; Bromme, D. Chem. Rev. 2002, 102, 4459   DOI   ScienceOn
14 Turk, B.; Turk, D.; Turk, V. Biochim. Biophys. Acta 2000, 1477(1-2), 98   DOI   ScienceOn
15 Buhling, F.; Fengler, A.; Brandt, W.; Welte, T.; Ansorge, S.; Nagler, D. K. Adv. Exp. Med. Biol. 2000, 477, 241