• Bulletin of the Korean Chemical Society
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• v.29 no.8
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• pp.1467-1471
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• 2008

The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.