동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권4호
  • /
  • Pages.898-906
  • /
  • 2007
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

법제 유황 경구투여가 간독성에 미치는 영향

Effect of Oral Administration of Processed Sulphur on Hepatotoxicity

  • 송인선 (이미지한의원) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 유화승 (대전대학교 한의과대학 동서암센터)
  • Song, In-Sun (Image Oriental Medical Clinic) ;
  • Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University)
  • 발행 : 2007.08.25
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초록

This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.

키워드

참고문헌

  1. 본초학교수공저. 본초학. 6판. 서울, 영림사, pp 639-640, 1991
  2. 黃奭輯註. 神農本草經, 中醫古籍, pp 156-160, 1978
  3. 구정희, 김운애, 류경희, 정형도. 동양학개론. 서울, 여강출판사, p 442, 443, 1991
  4. 최귀헌, 김창한. 유황오리 추출물의 각종 암세포에 대한 생육억제 효과. 한국축산식품학회지 22(4):348-351, 2002
  5. 한국식품개발연구원. 유황오리와 일반오리의 영양 성분 분석 및 비교시험 보고서. 1999
  6. 김성훈, 서영배. 법제 유황이 실험적 골 질환에 미치는 영향. 대한동의병리학회지 10(1):79-87, 1996
  7. 윤원호, 황진용, 김창한. 유황오리로부터 항종양 활성 성분의 분리 및 정제. 한국축산식품학회지 24(3):293-297, 2004
  8. Choi, G.H., Kim, C.H. Growth inhibition of extracts from sulur feed duck meat against various tomor cell lines. Kor. J. Food Sci. Ani. resour. 22(4):348-351, 2002
  9. Barretine, B.F., Ruffin, B.G. Salt and gypsum as regulators of cottonseed meal intake. Miss.State Univ. Agri. Sta. Inform. Sheet. p 587, 1958
  10. Bouchard, R and H.R. Conrad. Sulphur requirement of lactating dairy cows. H. Utilization of sulphates, molasses and lignin-sulfonate. J. Dairy Sci. 56: 142, 1973
  11. 하배진. 간독성과 병리학적인 면에서 노두 사포닌의 효과. 한국생명과학학회지 16(2):186-191, 2006
  12. Chitturi, S., Farrel, G.C. Drig-induced liver disease. In: Schiff ER, Sorrell MF, Maddrey WC, ed. Schiff`s diseases of the liver, vol 2, 9th ed. Philadelphia: Lippin-cott williams & Wilkins. pp 1059-1127, 2003
  13. 김윤준, 약물 유인성 간염의 진단 및 치료: 대한소화기학회 총서. 간염. 2판. 서울, 군자출판사, pp 301-302, 2005
  14. Kessler, R.C,. Davis, R.B., Foster, D.F. et al. Long-term trends in the use of complementary and laternative medical therapies in the United States. Ann Intern Med. 135: 262-268, 2001 https://doi.org/10.7326/0003-4819-135-4-200108210-00011
  15. Benichou, C. criteria of drug-induced liver disorders. Report of an international consensus meeting. J hepatol. 11(2): 272-276, 1990 https://doi.org/10.1016/0168-8278(90)90124-A
  16. Kaplowitz, N. Causality assessment versus guilt-by-association in drug hepatology. 33(1):123-130, 2001 https://doi.org/10.1053/jhep.2001.20645
  17. Plaa, G.L. Hewitt, W.R. Detection and Evaluation of Chemically Induced Liver Injury in Principles and Methods of Toxicology (W. Hayesed.),(Raven Press). pp 599-628, 1989
  18. 김효정, 서경원, 박기숙. 우황청심원의 간독성시험 : 랫드에서의 급성 및 아급성시험. 식품의학안전본부 독성부, 13(3):265- 274, 1997
  19. Zimmerman, H.J., Seeff, L.B. Enzymes in hepatic desease in Diagnostic Enzymology (Coodley, E.L. Ed), (Lea and Febriger, Philadelphia). pp 1-38, 1970
  20. Cornelius, C.E. Liver function tests in the differntail diagnosis of hepatotoxicity in hepatotoxicology (Meeks, R.G., Harrison, S.D. and Bull, R.J. Eds), (CRC Press). pp 181-213, 1991
  21. 최진호. 가축영양에서의 유황, 한국토양비료학회, pp 100-119, 1988