Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytoprotective Constituents of the Stem Barks of Fraxinus rhynchophylla on Mouse Hippocampal HT22 Cells and Their Antioxidative Activity

물푸레나무 수피의 생쥐 해마 유래 HT22 세포 보호와 항산화 활성 물질

  • Jeong, Gil-Saeng (Institute for Radiological Imaging Science, Wonkwang University) ;
  • Yoon, Kwon-Ha (Institute for Radiological Imaging Science, Wonkwang University) ;
  • Kim, Hyun-Chul (Central R & D Center, Kwang Dong Pharmaceutical Co.) ;
  • Oh, Seung-Hwan (Central R & D Center, Kwang Dong Pharmaceutical Co.) ;
  • Kim, Myong-Jung (College of Pharmacy, Wonkwang University) ;
  • Kang, Dae-Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • 정길생 (원광대학교 익산방사선영상과학연구소) ;
  • 윤권하 (원광대학교 익산방사선영상과학연구소) ;
  • 김현철 (광동제약) ;
  • 오승환 (광동제약) ;
  • 김명중 (원광대학교 약학대학) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원) ;
  • 김윤철 (원광대학교 약학대학)
  • Published : 2007.09.30
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Abstract

Phytochemical investigation of the MeOH extract of the dried stem barks of Fraxinus rhynchophylla Hance (Oleaceae), as guided by cytoprotective activity against tert-butyl hydroperoxide (t-BHP)-induced cell injury in mouse hippocampal HT22 cells, furnished two coumarins, esculetin (1) and fraxetin (2). Compounds 1 and 2 had the significant cytoprotective effects on t-BHP-induced cellular oxidative injury in HT22 cells. Furthermore, compounds 1 and 2 showed potent DPPH radical scavenging effect, exhibiting $IC_{50}$ values of 14.68 and 9.64 ${\mu}M$, respectively.

Keywords

References

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