Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Chemical constituents from the whole plants of Euphorbia supina Rafin

애기땅빈대의 화학적 성분

  • An, Ren-Bo (College of Pharmacy, Yanbian University) ;
  • Kwon, Ji-Wung (College of Life Sciences and Natural Resources, Wonkwang University) ;
  • Kwon, Tae-Oh (College of Life Sciences and Natural Resources, Wonkwang University) ;
  • Chung, Wan-Tae (Nutrition Physiology Division, National Livestock Research Institute Rural Development Administration) ;
  • Lee, Hye-Suk (College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • Published : 2007.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Eight compounds were isolated from the whole plants of Euphorbia supina (Euphorbiaceae) through repeated silica gel, YMC gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as 7-hydroxy-6-methoxycoumarin (scopoletin) (1), p-hydroxybenzaldehyde (2), methyl gallate (3), gallic acid (4), quercetin (5), quercetin $3-O-{\alpha}-L-arabinofuranoside$ (avicularin) (6), kaempferol $3-O-{\alpha}-L-arabinofuranoside$ (juglanin) (7) and kaempferol $3-O-{\beta}-D-glucopyranoside$ (astragaline) (8) by spectroscopic (NMR and MS) analysis.

Keywords

References

  1. 국가중의약관리국<중화본초> 편위회 (1999) 중화본초(전집), 4, 789-792. 상해과학기술출판사, 상해
  2. 이창복 (1989) 대한식물도감, 511. 향문사, 서울
  3. Tanaka, R. and Matsunaga, S. (1991) Fernane and multiflorane triterpene ketols from Euphorbia supina. Phytochemistry 30: 4093-4097 https://doi.org/10.1016/0031-9422(91)83474-Y
  4. Tanaka, R. and Matsunaga, S. (1991) Fernane and unusually migrated fernane triterpene-triones from Euphorbia supina. Phytochemistry 30: 293-296 https://doi.org/10.1016/0031-9422(91)84140-N
  5. Tanaka, R., Kurimoto, M., Yoneda, M. and Matsunaga, S. (1990) $17{\beta},21{\beta}-Epoxyhopan-3{\beta}-ol\;and\;{\beta}$-alnincanol from Euphorbia supina. Phytochemistry 29: 2253-2256 https://doi.org/10.1016/0031-9422(90)83047-5
  6. Tanaka, R. and Matsunaga, S. (1989) Supinenolones A, B and C, fernane-type triterpenoids from Euphorbia supina. Phytochemistry 28: 3149-3154 https://doi.org/10.1016/0031-9422(89)80296-1
  7. Tanaka, R., Matsunaga, S., Ishida, T. and Shingu, T. (1989) Four novel 3,4-seco-triterpenoids, espinendiols A and B, espinenoxide, and trisnor-isoespinenoxide from Euphorbia supina. Tetrahedron Lett. 30: 1661-1664 https://doi.org/10.1016/S0040-4039(00)99547-9
  8. Tanaka, R. and Matsunaga, S. (1988) Triterpene constituents from Euphorbia supina. Phytochemistry 27: 3579-3584 https://doi.org/10.1016/0031-9422(88)80772-6
  9. Tanaka, R., Matsuda, M. and Matsunaga, S. (1987) 3${\beta}$ - Hydroxyhexanordammaran-20-one from Euphorbia supina. Phytochemistry 26: 3365-3366 https://doi.org/10.1016/S0031-9422(00)82513-3
  10. Chung, B. S. and Kim, H. G. (1985) Studies on the terpenoid constituents of Euphorbia supina Rafin. Kor. J. Pharmacogn. 16: 155-159
  11. Matsunaga, S. and Morita, R. (1983) Hopenol-B, a triterpene alcohol from Euphorbia supina. Phytochemistry 22: 605-606 https://doi.org/10.1016/0031-9422(83)83063-5
  12. Tanaka, R. and Matsunaga, S. (1989) Loliolide and olean-12-en-3${\beta},\;9{\alpha},\;11{\alpha}$-triol from Euphorbia supina. Phytochemistry 28: 1699-1702 https://doi.org/10.1016/S0031-9422(00)97828-2
  13. Agata, I., Hatano, T., Nakaya, Y., Sugaya, T., Nishibe, S., Yoshida, T. and Okuda, T. (1991) Tannins and related polyphenols of Euphorbiaceous plants. VIII. Eumaculin A and eusupinin A, and accompanying polyphenols from Euphorbia maculata L. and E. supina Rafin. Chem. Pharm. Bull. 39: 881-883 https://doi.org/10.1248/cpb.39.881
  14. Lee, S. H., Tanaka, T., Nonaka, G. and Nishioka, I. (1991) Tannins and related compounds. CV. Monomeric and dimeric hydrolyzable tannins having a dehydrohexahydroxydiphenoyl group, supinanin, euphorscopin, euphorhelin and jolkianin, from Euphorbia species. Chem. Pharm. Bull. 39: 630-638 https://doi.org/10.1248/cpb.39.630
  15. Fang, Z., Zeng, X., Zhang, Y. and Zhou, G. (1993) Chemical constituents of spotted leaf euphorbia (Euphorbia supina). Zhongcaoyao 24: 230-233
  16. Chang, B. S., Kwon, Y. S. and Kim, C. M. (2004) The chemical structures and their antioxidant activity of the components isolated from the heartwood of Hemiptelea davidii. Kor. J. Pharmacogn. 35: 80-87
  17. Nam, J. H., Choi, S. Z. and Lee, K. R. (2004) Phytochemical constituents of Synurus excelsus. Kor. J. Pharmacogn. 35: 116-121
  18. Jang, D. S., Han, A.-R., Park, G., Jhon, G.-J. and Seo, E.-K. (2004) Flavonoids and aromatic compounds from the rhizomes of Zingiber zerumbet. Arch. Pharm. Res. 27: 386-389 https://doi.org/10.1007/BF02980078
  19. Redwane, A., Lazrek, H. B., Bouallam, S., Markouk, M., Amarouch, H. and Jana, M. (2002) Larvicidal activity of extracts from Quercus lusitania var. infectoria galls (Oliv.). J. Ethnopharmacol. 79: 261-263 https://doi.org/10.1016/S0378-8741(01)00390-7
  20. Lee, S. H., Tanaka, T., Nonaka, G. and Nishioka, I. (1990) Tannins and related compounds. XCV. Isolation and characterization of helioscopinins and helioscopins, four new hydrolyzable tannins from Euphorbia helioscopia L. (1). Chem. Pharm. Bull. 38: 1518-1523 https://doi.org/10.1248/cpb.38.1518
  21. Shen, C. C., Chang, Y. S. and Ho, L. K. (1993) Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids. Phytochemistry 34: 843-845 https://doi.org/10.1016/0031-9422(93)85370-7
  22. Zhang, X. F., Thuong, P. T., Jin, W. Y., Su, N. D., Sok, D. E., Bae, K. H. and Kang, S. S. (2005) Antioxidant activity of anthraquinones and flavonoids from flower of Reynoutria sachalinensis. Arch. Pharm. Res. 28: 22-27 https://doi.org/10.1007/BF02975130
  23. Jung, H. A., Kim, A. R., Chung, H. Y. and Choi, J. S. (2002) In vitro antioxidant activity of some selected Prunus species in Korea. Arch. Pharm. Res. 25: 865-872 https://doi.org/10.1007/BF02977006
  24. Jung, H. A., Kim, J. E., Chung, H. Y. and Choi, J. S. (2003) Antioxidant principles of Nelumbo nucifera stamens. Arch. Pharm. Res. 26: 279-285 https://doi.org/10.1007/BF02976956