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Cytoprotective Constituents of the Stem Barks of Fraxinus rhynchophylla on Mouse Hippocampal HT22 Cells and Their Antioxidative Activity  

Jeong, Gil-Saeng (Institute for Radiological Imaging Science, Wonkwang University)
Yoon, Kwon-Ha (Institute for Radiological Imaging Science, Wonkwang University)
Kim, Hyun-Chul (Central R & D Center, Kwang Dong Pharmaceutical Co.)
Oh, Seung-Hwan (Central R & D Center, Kwang Dong Pharmaceutical Co.)
Kim, Myong-Jung (College of Pharmacy, Wonkwang University)
Kang, Dae-Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.3, 2007 , pp. 287-290 More about this Journal
Abstract
Phytochemical investigation of the MeOH extract of the dried stem barks of Fraxinus rhynchophylla Hance (Oleaceae), as guided by cytoprotective activity against tert-butyl hydroperoxide (t-BHP)-induced cell injury in mouse hippocampal HT22 cells, furnished two coumarins, esculetin (1) and fraxetin (2). Compounds 1 and 2 had the significant cytoprotective effects on t-BHP-induced cellular oxidative injury in HT22 cells. Furthermore, compounds 1 and 2 showed potent DPPH radical scavenging effect, exhibiting $IC_{50}$ values of 14.68 and 9.64 ${\mu}M$, respectively.
Keywords
Fraxinus rhynchophylla; HT22; t-butyl hydroperoxide; cytoprotective effect; DPPH radical scavenging;
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Times Cited By KSCI : 5  (Citation Analysis)
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