전기학회논문지 (The Transactions of The Korean Institute of Electrical Engineers)

  • 제56권10호
  • /
  • Pages.1836-1843
  • /
  • 2007
  • /
  • 1975-8359(pISSN)
  • /
  • 2287-4364(eISSN)
대한전기학회 (The Korean Institute of Electrical Engineers)
권호 표지

AIDS환자 치료를 위한 NvBAT 치료기법: RTI에 대한 PI의 우수성

NvBAT Treatment for AIDS Patients: The Superiority of PI Over RTI

  • 조남훈 (숭실대 공대 전기공학부)
  • 발행 : 2007.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In this paper, we study the NvBAT treatment for AIDS patients that is combined with PI rather than RTI, while the Previous results have been focused on the NvBAT in conjuction with RTI. To this end, we obtain a bifurcation diagram which shows a change in the equilibrium points, and in their stability properties as the PI drug effect is varied. Based on the bifurcation diagram, we show that the NvBAT can be combined with drug PI for the treatment of AIDS patients. Various computer simulation results are included, which show the superiority of the NvBAT with PI over that with RTI. Accordition to simulation result, the NvBAT combined with PI is able to keep virus load level lower than that combined with RTI, which is crucial to avoid the emergence of drug-resistant mutants. Moreover, it is shown that, for some AIDS patients, NvBAT with RTI cannot make patients into long term non-progressor, while NvBAT with PI can.

키워드

참고문헌

  1. J.S. James, 'Human Retroviruses and Related Infections,' Major U.S. Scientific AIDS Conference, Feb. 1995. (Available at http://www.aids.org/atn/a-216-01.html.)
  2. 김세종, 면역학길라잡이, 고려의학, 2000
  3. D. Wodarz and M.A. Nowak, 'Specific therapy regimes could lead to long-term immunological control of HIV,' PNAS, vol. 96, pp. 14464-14469, December 1999 https://doi.org/10.1073/pnas.96.25.14464
  4. D. Wodarz and M.A. Nowak, 'Mathematical models of HIV pathogenesis and treatment,' BioEssays, vol. 24, pp. 1178-1187, Wiley Periodicals, 2002 https://doi.org/10.1002/bies.10196
  5. R. Zurakowski and A.R. Teel, 'A model predictive control based scheduling method for HIV therapy,' J. of Theoretical Biology, vol. 238, pp. 368-382, 2006 https://doi.org/10.1016/j.jtbi.2005.05.004
  6. H. Shim, S.J. Han, C.C. Chung, S.W. Nam, and J.H. Seo, 'Optimal Scheduling of Drug Treatment for HIV Infection: Continuous Dose Control and Receding Horizon Control,' International Journal of Control, Automation, and Systems, Vol. 1, No.3, pp.401-407, Sep., 2003
  7. H. Shim and Nam H. Jo, 'A simple condition for checking Non-vanishing Basin of Attraction Stability for a Class of Positive Nonlinear Systems,' Proceedings of the 44th IEEE Conference on Decision and Control, Dec., 12-15, 2005, Seville, Spain, pp. 5456-5461, also submitted to IEEE Trans. on Automatic Control
  8. H.J. Chang, H. Shim and J.H. Seo, 'Control of Immune Response of HIV Infection Model by Gradual Reduction of Drug Dose,' 43rd IEEE Conference on Decision and Control, Vol. 1, pp.l048-1054, Dec., 2004
  9. H. Shim, N.H. Jo, H. Chang and J.H. Seo, 'Feasibility of Achieving Long-term Non-progressor for AIDS Patient and NvBA-stability-based Treatment', under review for possible publication in IEEE Trans. on Automatic Control, 2007
  10. 이강현, 조남훈, 'AIDS환자 치료를 위한 점진적 약물감소기법에 감염속도상수가 미치는 영향,' 전기학회 논문지, Vol. 56, No. 1, pp. 174-182, Jan., 2007
  11. S. Kubiak, H. Lehr, R. Levy, T. Moeller, A. Parker, and E. Swin, 'Modeling control of HIV infection through structured treatment interruptions with recommendations for experimental protocol,' CRSC Technical Report (CRSC-TR01-27), 2001
  12. 생명과학교재연구회, 생명과학, 광림사, 2005