Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Estimation Method for Brain Activities are Influenced by Blood Pulsation Effect

Blood Pulsation의 효과가 뇌 활성화에 미치는 영향을 알아보는 방법

  • Lee, W.H. (Department of Biomedical Engineering, Hanyang University) ;
  • Ku, J.H. (Department of Biomedical Engineering, Hanyang University) ;
  • Lee, H.R. (Department of Biomedical Engineering, Hanyang University) ;
  • Han, K.W. (Department of Biomedical Engineering, Hanyang University) ;
  • Park, J.S. (Department of Biomedical Engineering, Hanyang University) ;
  • Kim, J.J. (Institute of Behavioral Science in Medicine, Yonsei University Severance Mental Health Hospital) ;
  • Yoon, K.J. (St.Peter's Hospital) ;
  • Kim, I.Y. (Department of Biomedical Engineering, Hanyang University) ;
  • Kim, S.I. (Department of Biomedical Engineering, Hanyang University)
  • 이원호 (한양대학교 의용생체공학과) ;
  • 구정훈 (한양대학교 의용생체공학과) ;
  • 이형래 (한양대학교 의용생체공학과) ;
  • 한기완 (한양대학교 의용생체공학과) ;
  • 박진식 (한양대학교 의용생체공학과) ;
  • 김재진 (연세대학교 정신건강병원 행동과학 연구실) ;
  • 윤강준 (강남 베드로 병원) ;
  • 김인영 (한양대학교 의용생체공학과) ;
  • 김선일 (한양대학교 의용생체공학과)
  • Published : 2007.06.30
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Abstract

BOLD T2*-weighted MR images reflects cortical blood flow and oxygenation alterations. fMRI study relies on the detection of localized changes in BOLD signal intensity. Since fMRI measures the very small modulations in BOLD signal intensity that occur during changes in brain activity, it is also very sensitive to small signal intensity variations caused by physiologic noise during the scan. Due to the complexity of movement of various organs associated with heart beat, it is important to reduce cardiac related noise rather than other physiological noise which could be required with relatively simple method. Therefore, a number of methods have been developed for the estimation and reduction of cardiac noise in fMRI study. But, each method has limitation. In this study, we proposed a new estimation method for brain activities influenced by blood pulsation effect using regression analysis with blood pulsation signal and the correspond slice of fMRI. We could find out that the right anterior cingulate cortex and right olfactory cortex and left olfactory cortex were largely influenced by blood pulsation effect for new method. These observed areas are mostly on the structure of anterior cerebral artery in the brain. That is convinced with that our method would be valid and our new method is easier to apply in practice and reduce computational burden than the retrospective method.

Keywords

References

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