Wild Ginseng Exerts Anti-inflammatory Effects via $NF-{\kappa}B$ inactivation in RAW 264.7 Cells

장뇌산삼의 $NF-{\kappa}B$ 억제를 통한 RAW 264.7 세포에서의 항염증 효과

  • Ahn, Sang-Hyun (Department of Anatomy, Department of Physiology, Oriental Medicine College) ;
  • Kim, Jin-Tack (Department of Anatomy, Department of Physiology, Oriental Medicine College) ;
  • Shin, Heung-Mook (Department of Physiology, Oriental Medicine College, Oriental Medical Bio-Renovatio Institute, Dongguk University)
  • 안상현 (동국대학교 한의과대학 해부학교실, 생리학교실) ;
  • 김진택 (동국대학교 한의과대학 해부학교실, 생리학교실) ;
  • 신흥묵 (생리학교실, 동국대학교 한의바이오혁신사업단)
  • Published : 2007.04.25

Abstract

Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are important inflammatory mediators that have been implicated in pathogenesis of inflammation and certain types of human cancers. The present study was designed in order to determine whether Wild ginseng (Panax ginseng C. A. Mayer) could modulate $I{\kappa}B$-kinase (IKK), iNOS and COX-2 gene expression and its immune responses in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS, 1 ${\mu}/m{\ell}$). Wild ginseng extract dose-dependantly (*0.5 - 2 ${\mu}/m{\ell}$) decreased the LPS-induced IKK, iNOS and COX-2 mRNA expression and its immune responses. Moreover, it inhibited unclear factor (NF)-${\kappa}B$ immune response by LPS. These data be likely to indicate that Wild ginseng may acts as inflammatory regulator and may be possible to develope a useful agent for inflammatory diseases.

Keywords

References

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