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Wild Ginseng Exerts Anti-inflammatory Effects via $NF-{\kappa}B$ inactivation in RAW 264.7 Cells  

Ahn, Sang-Hyun (Department of Anatomy, Department of Physiology, Oriental Medicine College)
Kim, Jin-Tack (Department of Anatomy, Department of Physiology, Oriental Medicine College)
Shin, Heung-Mook (Department of Physiology, Oriental Medicine College, Oriental Medical Bio-Renovatio Institute, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.2, 2007 , pp. 498-503 More about this Journal
Abstract
Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are important inflammatory mediators that have been implicated in pathogenesis of inflammation and certain types of human cancers. The present study was designed in order to determine whether Wild ginseng (Panax ginseng C. A. Mayer) could modulate $I{\kappa}B$-kinase (IKK), iNOS and COX-2 gene expression and its immune responses in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS, 1 ${\mu}/m{\ell}$). Wild ginseng extract dose-dependantly (*0.5 - 2 ${\mu}/m{\ell}$) decreased the LPS-induced IKK, iNOS and COX-2 mRNA expression and its immune responses. Moreover, it inhibited unclear factor (NF)-${\kappa}B$ immune response by LPS. These data be likely to indicate that Wild ginseng may acts as inflammatory regulator and may be possible to develope a useful agent for inflammatory diseases.
Keywords
Wild ginseng; RAW 264.7 macrophages; IKK; iNOS; COX-2; $NF-{\kappa}B$; Inflammatory diseases;
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