Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Extracts from Acanthopanax sessiliflorus SEEM Following Gamma-ray Irradiation on Solid Tumor and Immune Cells in Mice

방사선이 조사된 오갈피 나무의 추출물이 생쥐의 복강암 및 면역세포에 미치는 영향

  • Kim, Hyung-Woo (Department of Herbology, College of Oriental Medicine, Dongshin University) ;
  • Cho, Su-In (Department of Herbology, College of Oriental Medicine, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Jeon, Byung-Gwan (Department of Environmental Engineering, Dongshin University) ;
  • Cho, Young-Lim (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
  • 김형우 (동신대학교 한의과대학 본초학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실) ;
  • 김계엽 (동신대학교 물리치료학과) ;
  • 전병관 (동신대학교 환경공학과) ;
  • 조영림 (동신대학교 한의과대학 병리학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실)
  • Published : 2007.06.25
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Abstract

Acanthopanax sessiliflorus SEEM extracts(AS) have been used to treat patient with diseases including cancer in Oriental countries. Recently, AS was known to have anti-cancer and immuno-stimulating activites. For these reasons, we investigated the effects of AS following gamma-ray irradiation on cytotoxicity for solid tumor cell line (S-180) and immune-potentiating ability such as proliferation of thymocytes and splenocytes. Finally we also investigated tumor weight and survival rate in tumor bearing mice. In our results, Treatment with AS suppressed proliferation of solid tumor cells (S-180) effectively. Treatment with AS accelerated thymocyte and splenocyte proliferation in tumor bearing mice. In addition, Treatment with AS reduced tumor weight and prolonged life of tumor bearing mice. In conclusion, we demonstrate that AS following gamma-ray irradiation is useful to treat patients with cancer, and also demonstrate that AS have both direct cytotoxic ability for cancer cells and indirect immune-stimulating action for thymocytes and splenocytes.

Keywords

References

  1. Wen, M.C., Wei, C.H., Hu, Z.Q., Srivastava, K., Ko, J., Xi, S.T. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J. Allergy Clin Immunol. 116: 517-524, 2005 https://doi.org/10.1016/j.jaci.2005.05.029
  2. 全國韓醫科大學 本草學敎授 共編. 本草學. 永林社, 서울, pp 283-284, 1999
  3. 康秉秀, 金永坂 共編著. 方劑의 體系的 構成을 위한 臨床配合本草學. 永林社, 서울, pp 644-645, 1996
  4. Brekhman, I.I., Dardymov, I.V. "Nauka" Publishers Leningrad through 1st International Symposium of gerontology Lugano. Lloydia 32: 46, 1969
  5. 이인중, 김길웅. 약용식물(음나무, 오가피)로부터 생리활성 물질 검정. 한국잡초학회 7(3):289-299, 1987
  6. Davydov, M., Krikorian, A.D. Eleutherococcus senticosus Maxim. (Araliaceae) as an adaptogen: a closer look. J. Ethnopharmacol 72: 345-393, 2000 https://doi.org/10.1016/S0378-8741(00)00181-1
  7. Park, M.S., Kim, Y.J., Park, H.K., Chang, Y.S., Lee, J.H. Using air temperature and sunshine duration data to select seed production site for Eleutherococcus Senticosus Max. Korean J. Crop Sci. 40: 444-450, 1995
  8. Park, H.K., Park, M.S., Kim, T.S., Kim, S., Choi, K.G., Park, K.H. Characteristic of embryo growth and dehiscence during the after-rip-ening period in Eleutherococcus senticosus. Korean J. Crop Sci. 42: 673-677, 1997
  9. Tkhor, L.F., Taranenko, G.A., Kozlov, Yu. P., Tr. Mok. Obshchest 1 spyt Prir. Otd Biol 16: 73-77, 1966, Chem Abstr 66: 779e, 1967
  10. 정종운, 이윤호, 강성길. 가시오가피 약침이 당뇨유발 억제 및 신장보호 활성에 미치는 영향. 대한침구학회지 20(3):1-14, 2003
  11. 김호철, 이상인, 안덕균. Human Monocyte의 IL-8 생산억제에 미치는 류마토이드관절염 치료제로서의 오가피의 효과. 대한본초학회지 10(1):49-59, 1995
  12. 김계엽, 김경윤, 정현우. 방사선 조사 마우스에서 오가피의 면역활성 효과. 동의생리병리학회지 20(3):670-674, 2006
  13. Wysocki, L.J. and Sato, V.L. 'Planning' for lymphocytes ; A method for cell selection. Proc. Nat1. Acad. Sci. 75(6):2844-2848, 1978
  14. Mizel, S.B., Rosenstreich, D.L. Regulation of lymphocyte-activating factor (LAF) production and secretion in P388D1 cells ; identification of high molecular weight precursors of LAF. J. Immunol. Methods 122(6):2173-2179, 1979
  15. 임종순. 오가피(Acanthopanacis cortex)추출물을 첨가한 발효김치의 급여가 생쥐의 면역작용에 미치는 영향. 대전대학교 한의학 논문집 12(1):1-9. 2004
  16. Jeong, S.C., Jeong, Y.T., Yang, B.K., Song, C.H. Chemical characteristics and immuno-stimulating properties of biopolymers extracted from Acanthopanax sessiliflorus. J. Biochem Mol Biol. 39(1):84-90, 2006 https://doi.org/10.5483/BMBRep.2006.39.1.084
  17. Huang, D.B., Ran, R.Z., Yu, Z.F. Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer. Zhongguo Zhong Yao Za Zhi. 30(8):621-624, 2005
  18. Ha, E.S., Hwang, S.H., Shin, K.S., Yu, K.W., Lee, K.H., Choi, J.S., Park, W.M., Yoon, T.J. Anti-metastatic activity of glycoprotein fractionated from Acanthopanax senticosus, involvement of NK-cell and macrophage activation. Arch Pharm Res. 27(2):217-224, 2004 https://doi.org/10.1007/BF02980109
  19. Renauld, J.C. New insights into the role of cytokines in asthma. J. Clin Pathol. 54(8):577-589, 2001 https://doi.org/10.1136/jcp.54.8.577