Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Dopamine D2 Receptor Gene TaqI A Polymorphism in Korean Social Phobia Patients : Preliminary Study

한국인 사회공포증 환자에서 도파민 D2 수용체 TaqI A 유전자 다형성 : 예비적 연구

  • Kim, Bum-Jo (Department of Psychiatry, Sungkunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Lim, Se-Won (Department of Psychiatry, Sungkunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Shin, Dong-Won (Department of Psychiatry, Sungkunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Oh, Kang-Seob (Department of Psychiatry, Sungkunkwan University School of Medicine, Kangbuk Samsung Hospital) ;
  • Lee, Min-Soo (Department of Psychiatry, Korea University College of Medicine)
  • 김범조 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 임세원 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 신동원 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 오강섭 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 이민수 (고려대학교 의과대학 신경정신과학교실)
  • Published : 2007.05.31
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Abstract

Objective : It is suggested that disturbance of dopaminergic system might be related to the possible mechanism of social phobia. The aim of this study was to investigate the possible association of DRD2 TaqI polymorphism and social phobia. Method : Fifty-one patients with social phobia and 200 comparison subjects were tested for DRD2 TaqI A polymorphism. The severity of social phobic symptoms was measured by self-report version of the Liebowitz Social Anxiety Scale(LSAS-SR) and Hamilton anxiety scale(HAM-A). Results : There was no signigicant difference in the genotype, allele frequency, A1 carrier frequency, and heterozygote frequency DRD2 TaqI A polymorphism between the social phobia patients and the control groups. However, we found significant decrease in somatic anxiety of the HAM-A in the patients having A2A2 homozygotes(p=0.014). In addition, patients having A1A2 heterozygotes showed more anxiety in two subscales (p=0.042 in anxiety, p=0.019 in performance) of the LSAS-SR. Conclusion : These results suggest that DRD2 A2 homozygote might have a protective role against somatic anxiety, and molecular heterosis of DRD2 TaqI A polymorphism might be related with more severe anxiety in social phobia.

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